Abstract

The ethanolic extract of Callisia fragrans aerial parts showed a significant strong in vivo anti-inflammatory and in vitro antioxidant activities with a high in vivo gastrointestinal safety profile and a very low in vitro cytotoxicity on peripheral blood mononuclear cells (PBMCs) with an IC₅₀ > 1000 μg/ml. The alcoholic extract of C. fragrans has been analysed by HPLC coupled to multiple-stage Linear Ion-Trap and Orbitrap High-Resolution mass spectrometry in negative electrospray ionisation mode (LC-ESI/LTQOrbitrap/MS/MSn). By this approach, it was possible to putatively identify 13 compounds, mainly organic acids, flavonoids, one steroid and one hydroxy-coumarin. Luteolin 6-C-glucopyranosyl-7-O-glucopyranoside, luteolin-8-C-glucopyranosyl-7-O-rhamnopyranoside, luteolin-6-C-glucoside and isoorientin 7-O-[6''-feruloyl]-glucoside were detected for the first time in C. fragrans and family Commelinaceae.

Chemical profiling and biological screening with potential anti-inflammatory activity of Callisia fragrans grown in EgyptAll authorsSamah M. El Sohafy ,Rasha A. Nassra,Gilda D’Urso,Sonia Piacente &Shaimaa M. Sallamhttps://doi.org/10.1080/14786419.2020.1791113

Published online:

10 July 2020

中文翻译：

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具有潜在抗炎活性的埃及香椿的化学分析和生物筛选

摘要

Callisia fragrans地上部分的乙醇提取物显示出很强的体内抗炎和体外抗氧化活性，具有很高的体内胃肠道安全性和非常低的体外对外周血单核细胞 (PBMC) 的细胞毒性，IC ₅₀ > 1000 微克/毫升。C. fragrans的酒精提取物已通过 HPLC 与多级线性离子阱和 Orbitrap 高分辨率质谱联用在负电喷雾电离模式 (LC-ESI/LTQOrbitrap/MS/MSn) 下进行分析。通过这种方法，可以推测识别出 13 种化合物，主要是有机酸、黄酮类化合物、一种类固醇和一种羟基香豆素。木犀草素-6- Ç吡喃葡萄糖基-7- ø吡喃葡萄糖苷，木犀草素-8- Ç吡喃葡萄糖基-7- ø -rhamnopyranoside，木犀草素6-C葡糖苷和异荭草素-7- ö - [6“” -阿魏酰葡糖苷分别为首次在C. fragrans和 Commelinaceae 中检测到。

化学分析和与潜在的抗炎活性生物筛选Callisia桂花生长在埃及的所有作者萨马赫M.萨尔瓦多Sohafy ，塔拉夏A. Nassra，吉尔达D'乌尔索，索尼娅Piacente＆Shaimaa M.萨拉姆https://doi.org/ 10.1080/14786419.2020.1791113

在线发布：

2020 年 7 月 10 日