Abstract

One novel ursolic acid derivative sabiracin 1 (11,25-epoxy-3β-hydroxy-urs-12-en-28-oic acid) was isolated from the leaves of Carissa carandas, together with five known compounds para hydroxy benzaldehyde (2), ursolic acid (3), carissin (4), 22α-hydroxyursolic acid (5) and β-sitosterol-3-O-β-D-glucopyranoside (6). Compounds 2 and 5 were isolated for the first time from this genus. Structure elucidation was done by the help of spectroscopic techniques. Compounds 1-3, 5 and 6 were examined against oral cancer (CAL-27) and lung cancer (NCI-H460) cell lines. 6 showed good activity against oral cancer (IC₅₀ 18.69 µM), moderate activity against lung cancer (IC₅₀ 63.34 µM) and no cytotoxicity against normal cell lines.

摘要

从Carissa carandas的叶子中分离出一种新的熊果酸衍生物 sabiracin 1 ( 11,25-epoxy-3 β -hydroxy- urs-12-en-28-oic acid )，以及五种已知化合物对羟基苯甲醛 ( 2 ) 。 、熊果酸 ( 3 )、carissin ( 4 )、22 α-羟基熊果酸( 5 ) 和β-谷甾醇-3-O- β -D-吡喃葡萄糖苷 ( 6 )。化合物2和5首次从该属中分离出来。借助光谱技术进行结构解析。化合物1 - 3，5和6进行了检查抗口腔癌（CAL-27）和肺癌（NCI-H460）的细胞系。6对口腔癌具有良好的活性 (IC ₅₀ 18.69 µM)，对肺癌具有中等活性 (IC ₅₀ 63.34 µM)，对正常细胞系没有细胞毒性。