ABSTRACT

Introduction

Due to overcome the hardness of the vaccine design, computational vaccinology is emerging widely. Prediction of T cell and B cell epitopes, antigen processing analysis, antigenicity analysis, population coverage, conservancy analysis, allergenicity assessment, toxicity prediction, and protein-peptide docking are important steps in the process of designing and developing potent vaccines against various viruses and cancers. In order to perform all of the analyses, several bioinformatics tools and online web servers have been developed. Scientists must take the decision to apply more suitable and precise servers for each part based on their accuracy.

Areas covered

In this review, a wide-range list of different bioinformatics tools and online web servers has been provided. Moreover, some studies were proposed to show the importance of various bioinformatics tools for predicting and developing efficient vaccines against different pathogens including viruses, bacteria, parasites, and fungi as well as cancer.

Expert opinion

Immunoinformatics is the best way to find potential vaccine candidates against different pathogens. Thus, the selection of the most accurate tools is necessary to predict and develop potent preventive and therapeutic vaccines. To further evaluation of the computational and in silico vaccine design, in vitro/in vivo analyses are required to develop vaccine candidates.

中文翻译：

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针对不同病原体和癌症的计算机疫苗设计概述。

摘要

介绍

由于克服了疫苗设计的难度，计算疫苗学正在广泛出现。在设计和开发针对各种病毒和癌症的有效疫苗的过程中，T细胞和B细胞表位的预测，抗原加工分析，抗原性分析，种群覆盖率，保守性分析，变应原性评估，毒性预测和蛋白肽对接是重要的步骤。为了执行所有分析，已经开发了几种生物信息学工具和在线Web服务器。科学家们必须根据其准确性决定为每个零件应用更合适，更精确的服务器。

覆盖区域

在这篇综述中，提供了各种生物信息学工具和在线Web服务器的广泛列表。此外，提出了一些研究，以表明各种生物信息学工具对于预测和开发针对不同病原体（包括病毒，细菌，寄生虫，真菌和癌症）的有效疫苗的重要性。

专家意见

免疫信息学是寻找针对不同病原体的潜在候选疫苗的最佳方法。因此，选择最准确的工具对于预测和开发有效的预防和治疗疫苗是必要的。为了进一步评估计算和计算机疫苗设计，需要进行体外/体内分析以开发候选疫苗。