Moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) exhibits multiple functions separate and distinct from its historic role in energy production. Further, it exhibits dynamic changes in its subcellular localization which is an a priori requirement for its multiple activities. Separately, moonlighting GAPDH may function in the pathology of human disease, involved in tumorigenesis, diabetes, and age-related neurodegenerative disorders. It is suggested that moonlighting GAPDH function may be related to specific modifications of its protein structure as well as the formation of GAPDH protein: protein or GAPDH protein: nucleic acid complexes.

中文翻译：

---

月光照下的3-磷酸甘油醛脱氢酶：正常细胞和人体病理学中的翻译后修饰，蛋白质和核酸相互作用。

月光照下的3-磷酸甘油醛脱氢酶（GAPDH）具有多种功能，与以往在能源生产中的作用不同。此外，它在其亚细胞定位中表现出动态变化，这是其多种活性的先决条件。另外，月光下的GAPDH可能在人类疾病的病理中起作用，涉及肿瘤发生，糖尿病和与年龄相关的神经退行性疾病。建议月光下的GAPDH功能可能与其蛋白质结构的特定修饰以及GAPDH蛋白质：蛋白或GAPDH蛋白质：核酸复合物的形成有关。