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Moonlighting glyceraldehyde-3-phosphate dehydrogenase: posttranslational modification, protein and nucleic acid interactions in normal cells and in human pathology.
Critical Reviews in Biochemistry and Molecular Biology ( IF 6.2 ) Pub Date : 2020-07-09 , DOI: 10.1080/10409238.2020.1787325
Michael A Sirover 1
Affiliation  

Moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) exhibits multiple functions separate and distinct from its historic role in energy production. Further, it exhibits dynamic changes in its subcellular localization which is an a priori requirement for its multiple activities. Separately, moonlighting GAPDH may function in the pathology of human disease, involved in tumorigenesis, diabetes, and age-related neurodegenerative disorders. It is suggested that moonlighting GAPDH function may be related to specific modifications of its protein structure as well as the formation of GAPDH protein: protein or GAPDH protein: nucleic acid complexes.



中文翻译:

月光照下的3-磷酸甘油醛脱氢酶:正常细胞和人体病理学中的翻译后修饰,蛋白质和核酸相互作用。

月光照下的3-磷酸甘油醛脱氢酶(GAPDH)具有多种功能,与以往在能源生产中的作用不同。此外,它在其亚细胞定位中表现出动态变化,这是其多种活性的先决条件。另外,月光下的GAPDH可能在人类疾病的病理中起作用,涉及肿瘤发生,糖尿病和与年龄相关的神经退行性疾病。建议月光下的GAPDH功能可能与其蛋白质结构的特定修饰以及GAPDH蛋白质:蛋白或GAPDH蛋白质:核酸复合物的形成有关。

更新日期:2020-09-02
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