The mechanism of S_NAr reactions between 2-chloro-5-nitropyrimidine with primary and secondary alicyclic amines, respectively, have been studied by kinetic measurements. The kinetic data obtained in aqueous media opens a controversial discussion based on Brönsted-type plots analysis. The first approach based on the kinetic data reveals a non-catalyzed pathway. Then, the subtlety of the mathematical treatment of the kinetic data is discussed over a concerted or stepwise mechanism, respectively.

中文翻译：

---

实验分析强调了 SNAr 反应中 Meisenheimer 复合物的稳定性，并朝着反应途径的趋势发展。

通过动力学测量研究了2-氯-5-硝基嘧啶分别与脂环伯胺和脂环仲胺之间的_SN Ar反应机理。在水介质中获得的动力学数据引发了基于布朗斯台德型图分析的有争议的讨论。第一种基于动力学数据的方法揭示了非催化途径。然后，分别通过协调或逐步机制讨论动力学数据数学处理的微妙之处。