Hypospadias and urethral stricture are common urological diseases which seriously affect voiding function and life quality of the patients, yet current clinical treatments often result in unsatisfactory clinical outcome with frequent complications. In vitro experiments confirmed that ICG-001 (a well-established Wnt signaling inhibitor) could effectively suppress fibroblast proliferation and fibrotic protein expression. In this study, we applied a novel drug-delivering nanoyarn scaffold in urethroplasty in dog model, which continuously delivers ICG-001 during tissue reconstruction, and could effectively promote urethral recovery and resume fully functional urethra within 12 weeks. Such attempts are essential to the development of regenerative medicine for urological disorders and for broader clinical applications in human patients.

中文翻译：

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使用核壳胶原蛋白/聚（丙交酯-共-己内酯）[P(LLA-CL)] 纳米纱支架，通过 ICG-001 递送促进功能性尿道的有效重建：狗模型研究

尿道下裂和尿道狭窄是泌尿科常见疾病，严重影响患者的排尿功能和生活质量，但目前临床治疗效果不佳，并发症多发。体外实验证实ICG-001（一种成熟的Wnt信号抑制剂）可以有效抑制成纤维细胞增殖和纤维化蛋白表达。在这项研究中，我们在狗模型尿道成形术中应用了一种新型的药物输送纳米纱支架，该支架在组织重建过程中持续输送 ICG-001，可有效促进尿道恢复，并在 12 周内恢复全功能尿道。这些尝试对于泌尿系统疾病再生医学的发展和人类患者更广泛的临床应用至关重要。