Triple-negative breast cancer is the worst prognosis in breast cancer, accounting for 10.0–20.8% of all breast cancers. Considering that triple-negative breast cancer has great heterogeneity and very poor prognosis, clinical medication guidance is in urgent need of a more detailed classification of breast cancer itself. Although many researchers have been dedicated to the clustering of triple-negative breast cancer and have found possible targets based on typing, their results are not closely related to the prognosis. This paper utilizes three clustering methods to retype the patient data with triple-negative breast cancer, and the results show that the triple-negative breast cancer data could be classified into two categories. Eight important genes and three important clinical factors related to the prognosis of two types of triple-negative breast cancer have been obtained. These genes have the following three characteristics: co-expression, differential expression and interaction. In terms of breast cancer control, the prognosis can be controlled as much as possible by regulating gene levels, which provides new directions and ideas for related research on breast cancer prognosis.

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基于聚类方法的三阴性乳腺癌再分型

三阴性乳腺癌是乳腺癌中预后最差的一种，占所有乳腺癌的10.0%～20.8%。考虑到三阴性乳腺癌异质性大、预后极差，临床用药指导急需对乳腺癌本身进行更详细的分类。尽管许多研究人员一直致力于三阴性乳腺癌的聚类，并根据分型找到了可能的靶点，但他们的结果与预后并没有密切关系。本文利用三种聚类方法对三阴性乳腺癌患者数据进行重新分型，结果表明三阴性乳腺癌数据可以分为两类。获得了与两种类型三阴性乳腺癌预后相关的8个重要基因和3个重要临床因素。这些基因具有以下三个特征：共表达、差异表达和相互作用。在乳腺癌的控制方面，通过调控基因水平尽可能地控制预后，为乳腺癌预后的相关研究提供了新的方向和思路。