In this study, we investigated the changes of quantitative dynamic contrast‐enhanced (DCE)‐MRI parameters using a reference region (RR) model for the breast invasive ductal carcinoma (IDC). We retrospectively analyzed 80 cases with pathologically confirmed IDC using quantitative DCE‐MRI with a RR model. The pharmacokinetic quantitative parameters and prognostic factors of IDC were measured, and the relationship between them was examined. The volume transfer constant (RRK^trans) and rate constant (K_ep) were significantly higher in patients with level 3 histological grading compared to patients with level 1 & 2 histological grading (p < 0.05), and patients with negative estrogen receptor (ER‐negative) and/or negative progesterone receptor (PR‐negative) compared to patients with ER‐positive (p < 0.05) and/or PR‐positive (p < 0.05), and Triple‐Negative Breast Cancer (TNBC) type compared to luminal type breast cancer, respectively. Our results demonstrated that high RRK^trans and Kep values were associated with TNBC type. In addition, RRK^trans and K_ep parameters can differentiate luminal type and TNBC type breast cancer.

中文翻译：

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使用参考区域模型评估浸润性导管癌（IDC）患者的定量动态对比增强（DCE）-MRI参数

在本研究中，我们使用乳腺浸润性导管癌（IDC）的参考区域（RR）模型研究了定量动态对比增强（DCE）-MRI参数的变化。我们回顾性分析了80例经病理证实的IDC，并使用RR模型定量DCE-MRI。测量IDC的药代动力学定量参数和预后因素，并检查它们之间的关系。体积传递常数（RRK ^trans）和速率常数（K _ep）在3级组织学分级的患者中明显高于1和2级组织学分级的患者（p <0.05），雌激素受体阴性（ER阴性）和/或孕激素受体阴性（PR阴性）的患者相比与腔内型乳腺癌相比，分别为ER阳性（p <0.05）和/或PR阳性（p <0.05）和三阴性乳腺癌（TNBC）类型的患者。我们的结果表明高RRK^反式和Kep值与TNBC类型有关。此外，RRK ^trans和K _ep参数可以区分管腔型和TNBC型乳腺癌。