Near‐infrared spectroscopy (NIRS) has been proposed as a noninvasive modality for detecting complications in patients undergoing extracorporeal membrane oxygenation (ECMO), and it can simultaneously reveal the global circulatory status of these patients. We optimized ECMO therapy on the basis of real‐time peripheral NIRS probing. Three patients underwent venoarterial (VA) ECMO and one patient underwent venovenous (VV) ECMO. All patients received peripheral ECMO cannulation with routine distal perfusion catheter placement. We designed an experimental protocol to adjust ECMO blood flow over 1 hour. Hemodynamic responses were measured using NIRS devices attached to the calf at approximately 60% of the distance from the ankle to the knee. HbO₂ levels change substantially with adjustments in ECMO flow, and they are more sensitive than HHb levels and the tissue saturation index (TSI) are. NIRS for optimizing ECMO therapy may be reliable for monitoring global circulatory status.

中文翻译：

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使用近红外光谱法评估外周血流变化优化体外膜氧合治疗：一项前瞻性研究。

近红外光谱法（NIRS）已被建议作为一种无创方法来检测接受体外膜氧合（ECMO）的患者的并发症，并且它可以同时揭示这些患者的整体循环状态。我们在实时外围NIRS探测的基础上优化了ECMO治疗。3例患者接受了动静脉（VA）ECMO，1例患者接受了动静脉（VV）ECMO。所有患者均接受常规远端灌注导管置入的外周ECMO插管。我们设计了一个实验方案来调整ECMO在1小时内的血流量。使用附着在小腿上的NIRS设备在从脚踝到膝盖的距离的大约60％处测量血流动力学反应。HbO ₂ECMO流量的调整会显着改变血红蛋白水平，并且它们比HHb水平和组织饱和指数（TSI）更敏感。用于优化ECMO治疗的NIRS对于监测整体循环状况可能是可靠的。