Th17/Treg imbalance modulates rat myocardial fibrosis and heart failure by regulating LOX expression.,Acta Physiologica

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Th17/Treg imbalance modulates rat myocardial fibrosis and heart failure by regulating LOX expression.
Acta Physiologica ( IF 5.6 ) Pub Date : 2020-07-10 , DOI: 10.1111/apha.13537
Min Lu ₁ , Xinglei Qin ₂ , Jungong Yao ₁ , Yuanyuan Yang ₁ , Minghu Zhao ₁ , Lin Sun ₁

Affiliation

The imbalance of T helper (Th) 17/T regulatory (Treg) is involved in chronic heart failure (HF). The enzyme lysyl oxidase (LOX) contributes to myocardial fibrosis. This study was designed to decipher the regulatory mechanism of Th17/Treg on LOX expression and to validate whether Th17/Treg imbalance regulates myocardial fibrosis by modulating LOX expression.

中文翻译：

Th17/Treg 失衡通过调节 LOX 表达调节大鼠心肌纤维化和心力衰竭。

T 辅助 (Th) 17/T 调节 (Treg) 的失衡与慢性心力衰竭 (HF) 相关。赖氨酰氧化酶 (LOX) 会导致心肌纤维化。本研究旨在破译 Th17/Treg 对 LOX 表达的调控机制，并验证 Th17/Treg 失衡是否通过调节 LOX 表达来调节心肌纤维化。

更新日期：2020-07-10

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