Structural correlates of atypical visual and motor cortical oscillations in pediatric-onset multiple sclerosis.,Human Brain Mapping

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Structural correlates of atypical visual and motor cortical oscillations in pediatric-onset multiple sclerosis.
Human Brain Mapping ( IF 3.5 ) Pub Date : 2020-07-10 , DOI: 10.1002/hbm.25126
Amy T Waldman _{1,

2} , John R Sollee ₁ , Ritobrato Datta ₁ , Amy M Lavery ₁ , Geraldine Liu ₁ , Tomas S Aleman ₃ , Brenda L Banwell _{1,

2} , William C Gaetz ₄

Affiliation

We have previously demonstrated that pediatric‐onset multiple sclerosis (POMS) negatively impacts the visual pathway as well as motor processing speed. Relationships between MS‐related diffuse structural damage of gray and white matter (WM) tissue and cortical responses to visual and motor stimuli remain poorly understood. We used magnetoencephalography in 14 POMS patients and 15 age‐ and sex‐matched healthy controls to assess visual gamma (30–80 Hz), motor gamma (60–90 Hz), and motor beta (15–30 Hz) cortical oscillatory responses to a visual‐motor task. Then, 3T MRI was used to: (a) calculate fractional anisotropy (FA) of the posterior visual and corticospinal motor WM pathways and (b) quantify volume and thickness of the cuneus and primary motor cortex. Visual gamma band power was reduced in POMS and was associated with reduced FA of the optic radiations but not with loss of cuneus volume or thickness. Activity in the primary motor cortex, as measured by postmovement beta rebound amplitude associated with peak latency, was decreased in POMS, although this reduction was not predicted by structural metrics. Our findings implicate loss of WM integrity as a contributor to reduced electrical responses in the visual cortex in POMS. Future work in larger cohorts will inform on the cognitive implications of this finding in terms of visual processing function and will determine whether the progressive loss of brain volume known to occur in POMS ultimately contributes to both progressive dysfunction in such tasks as well as progressive reduction in cortical electrical responses in the visual cortex.

中文翻译：

儿科多发性硬化症中非典型视觉和运动皮层振荡的结构相关性。

我们之前已经证明，儿科发病的多发性硬化症 (POMS) 会对视觉通路和运动处理速度产生负面影响。MS 相关的灰质和白质 (WM) 组织的弥漫性结构损伤与皮层对视觉和运动刺激的反应之间的关系仍然知之甚少。我们对 14 名 POMS 患者和 15 名年龄和性别匹配的健康对照使用脑磁图来评估视觉伽马 (30-80 Hz)、运动伽马 (60-90 Hz) 和运动贝塔 (15-30 Hz) 皮质振荡反应视觉运动任务。然后，3T MRI 用于：(a) 计算后部视觉和皮质脊髓运动 WM 通路的分数各向异性 (FA)，以及 (b) 量化楔叶和初级运动皮层的体积和厚度。POMS 中的视觉伽马波段功率降低，并且与视辐射的 FA 降低有关，但与楔叶体积或厚度的损失无关。初级运动皮层的活动（通过与峰值潜伏期相关的运动后 β 反弹幅度来衡量）在 POMS 中有所减少，尽管结构指标并未预测到这种减少。我们的研究结果暗示 WM 完整性的丧失是 POMS 视觉皮层电反应减少的一个因素。在更大的队列中的未来工作将告知这一发现在视觉处理功能方面的认知影响，并将确定已知在 POMS 中发生的脑容量逐渐减少是否最终导致此类任务中的进行性功能障碍以及脑容量的逐渐减少。视觉皮层的皮层电反应。

更新日期：2020-07-10

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