Esophageal physiology—an overview of esophageal disorders from a pathophysiological point of view,Annals of the New York Academy of Sciences

当前位置： X-MOL 学术 › Ann. N. Y. Acad. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Esophageal physiology—an overview of esophageal disorders from a pathophysiological point of view
Annals of the New York Academy of Sciences ( IF 4.1 ) Pub Date : 2020-07-10 , DOI: 10.1111/nyas.14417
Christian Lottrup _{1,

2} , Abraham Khan ₃ , Vikram Rangan ₄ , John O Clarke ₅

Affiliation

The esophagus serves the principal purpose of transporting food from the pharynx into the stomach. A complex interplay between nerves and muscle fibers ensures that swallowing takes place as a finely coordinated event. Esophageal function can be tested by a variety of methods, endoscopy, manometry, and reflux monitoring being some of the most important. Regarding pathophysiology, motor disorders, such as achalasia, often cause dysphagia and/or chest pain. Functional esophageal disorders are a heterogeneous group with hypersensitivity as a dominant pathophysiological factor. Gastroesophageal reflux disease often causes symptoms, such as heartburn and regurgitation, and a spectrum of disease, ranging from minimal mucosal damage visible only in the microscope to esophageal ulcers and strictures in the most severe cases. Eosinophilic esophagitis is an immune‐mediated condition that can result in significant dysphagia and associated luminal narrowing. In the following, we will provide an overview of the most common esophageal disorders from a combined pathophysiological and clinical view.

中文翻译：

食管生理学——从病理生理学角度概述食管疾病

食道的主要作用是将食物从咽部输送到胃中。神经和肌肉纤维之间复杂的相互作用确保吞咽作为一个精细协调的事件发生。食管功能可以通过多种方法进行测试，内窥镜检查、测压和反流监测是最重要的一些方法。关于病理生理学，运动障碍，例如贲门失弛缓症，通常会导致吞咽困难和/或胸痛。功能性食管疾病是一个以超敏反应为主要病理生理因素的异质性群体。胃食管反流病通常会引起胃灼热和反流等症状，以及一系列疾病，从仅在显微镜下可见的微小粘膜损伤到最严重的食管溃疡和狭窄。嗜酸性粒细胞性食管炎是一种免疫介导的疾病，可导致严重的吞咽困难和相关的管腔狭窄。在下文中，我们将从病理生理学和临床相结合的角度概述最常见的食管疾病。

更新日期：2020-07-10

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11