Construction of Flexible-on-Rigid Hybrid-Phase Metal-Organic Frameworks for Controllable Multi-Drug Delivery.,Angewandte Chemie International Edition

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Construction of Flexible-on-Rigid Hybrid-Phase Metal-Organic Frameworks for Controllable Multi-Drug Delivery.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-07-10 , DOI: 10.1002/anie.202008858
Xiao-Gang Wang ₁ , Lei Xu ₁ , Min-Jie Li ₁ , Xian-Zheng Zhang ₁

Affiliation

Multi‐component MOFs contain multiple sets of unique and hierarchical pores, with different functions for different applications, distributed in their inter‐linked domains. Herein, we report the construction of a class of precisely aligned flexible‐on‐rigid hybrid‐phase MOFs with a unique rods‐on‐octahedron morphology. We demonstrated that hybrid‐phase MOFs can be constructed based on two prerequisites: the partially matched topology at the interface of the two frameworks, and the structural flexibility of MOFs with acs topology, which can compensate for the differences in lattice parameters. Furthermore, we achieved domain selective loading of multiple guest molecules into the hybrid‐phase MOF, as observed by scanning transmission electron microscopy–energy‐dispersive X‐ray spectrometry elemental mapping. Most importantly, we successfully applied the constructed hybrid‐phase MOF to develop a dual‐drug delivery system with controllable loading ratio and release kinetics.

中文翻译：

刚性-柔性混合相金属-有机框架的构建，可控制多种药物的输送。

多组分MOF包含多组独特且分层的孔，它们在相互关联的域中分布，针对不同的应用具有不同的功能。在此，我们报告了具有独特的八面体棒形结构的一类精确对准的刚柔混合型MOF的构造。我们证明了可以基于两个先决条件构建混合相MOF：两个框架的接口处的部分匹配拓扑，以及具有acs的MOF的结构灵活性拓扑，可以补偿晶格参数的差异。此外，通过扫描透射电子显微镜-能量色散X射线光谱元素映射，我们观察到了多个客体分子进入混合相MOF的区域选择性负载。最重要的是，我们成功地将构建的混合相MOF应用到可控负载率和释放动力学可控的双重药物输送系统中。

更新日期：2020-07-10

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