A Separation-Sensing Membrane Performing Precise Real-Time Serum Analysis During Blood Drawing.,Angewandte Chemie International Edition

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A Separation-Sensing Membrane Performing Precise Real-Time Serum Analysis During Blood Drawing.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-07-09 , DOI: 10.1002/anie.202008241
Zhenyu Chu ₁ , Wei Zhang _{1,

2} , Qiannan You ₁ , Xiaoyue Yao ₁ , Tao Liu ₁ , Gongping Liu ₁ , Guangru Zhang ₁ , Xiaoping Gu ₂ , Zhengliang Ma ₂ , Wanqin Jin ₁

Affiliation

Dynamic and on‐site analysis of serum from human blood is crucial, however, state‐of‐the‐art blood‐assay methods can only collect single or discrete data of physiological analytes; thus, the online reports of the dynamic fluctuation of key analytes remains a great challenge. Here, we propose a novel separation‐sensing membrane by constructing a heterogeneous‐nanostructured architecture, wherein a surface nanoporous layer continuously extracts serum, while the biosensing nanochannels underneath dynamically recognise biotargets, thereby achieving a continuous testing of vital clinical indices as blood is drawn. By precisely controlling the pore structure and nanoshape of biosensing crystals, this membrane achieved accurate and online glucose and lactate monitoring in patients with a variety of medical conditions within 1 min, which is one order of magnitude faster than state‐of‐the‐art techniques. Moreover, various kinds of bio‐recognisers can be introduced into this membrane to accurately detect glutamate, transaminase, and cancer biomarkers.

中文翻译：

在采血过程中执行精确实时血清分析的分离传感膜。

对人血中的血清进行动态和现场分析至关重要，但是，最新的血液分析方法只能收集生理分析物的单个或离散数据。因此，关键分析物动态波动的在线报告仍然是一个巨大的挑战。在这里，我们通过构建异质纳米结构，提出了一种新型的分离传感膜，其中表面纳米多孔层连续提取血清，而下方的生物传感纳米通道可动态识别生物靶标，从而在抽取血液时实现对重要临床指标的连续测试。通过精确控制生物传感晶体的孔结构和纳米形状，该膜可在1分钟内对各种医疗状况的患者进行准确的在线葡萄糖和乳酸监测，这比最先进的技术快一个数量级。此外，可以在该膜中引入各种生物识别器，以准确检测谷氨酸，转氨酶和癌症生物标志物。

更新日期：2020-07-09

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