Kalanchoe pinnata is a medicinal plant, used mainly in African, Brazilian, and Indian traditional medicine for the treatment of several human disorders. Whole leaf extracts, crude juice of the leaves, and aqueous and organic extracts of the leaves are used. Over the last decade, ethanolic extracts have become the most popular form of Kalanchoe medicinal preparation. In this study, an ethanolic extract of this plant leaf was tested in a battery of standard regulatory genetic toxicology tests. This extract did not induce reverse mutations in the Salmonella/microsome assay but induces a weak genotoxic response in the mouse lymphoma assay and the in vivo micronucleus assay in mice. Our results indicate that this material may cause DNA damage, and its use should be restricted.

Kalanchoe pinnata是一种药用植物，主要​​用于非洲、巴西和印度的传统医学，用于治疗多种人类疾病。使用全叶提取物、叶子的粗汁以及叶子的水和有机提取物。在过去十年中，乙醇提取物已成为最流行的长寿花药物制剂形式。在这项研究中，这种植物叶子的乙醇提取物在一系列标准的监管遗传毒理学测试中进行了测试。该提取物在沙门氏菌/微粒体试验中不诱导回复突变，但在小鼠淋巴瘤试验和小鼠体内微核试验中诱导微弱的基因毒性反应。我们的结果表明，这种材料可能会导致 DNA 损伤，因此应限制其使用。