In this commentary we argue that the hygiene hypothesis may apply to COVID-19 susceptibility and also that residence in low hygienic conditions acts to train innate immune defenses to minimize the severity of infection. We advocate that approaches, which elevate innate immune functions, should be used to minimize the consequences of COVID-19 infection at least until effective vaccines and antiviral therapies are developed.

中文翻译：

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卫生假设是否适用于COVID-19易感性？

在这篇评论中，我们认为卫生假说可能适用于COVID-19易感性，而且居住在低卫生条件下的行为是训练先天免疫防御以最大程度地降低感染的严重性。我们提倡至少在开发出有效的疫苗和抗病毒治疗之前，应采用能提高先天免疫功能的方法，以最大程度地减少COVID-19感染的后果。