Streptomyces sp. SCSIO 03032, isolated from a deep-sea sediment sample (−3412 m) from the Indian Ocean, produces several classes of bioactive compounds including α-pyridone antibiotics (piericidins), polycyclic macrolactams (heronamides) and bisindole alkaloids (spiroindimicins, indimicins and lynamicins). Here we report the complete genome sequence of Streptomyces sp. SCSIO 03032, which consists of a 6,287,975 bp linear chromosome. The genome analysis reveals the presence of 29 putative biosynthetic gene clusters for secondary metabolites, including those for piericidins, heronamides and spiroindimicins/indimicins/lynamicins. The genome sequence suggests that Streptomyces sp. SCSIO 03032 could be a producer for novel bioactive natural products with potential applications in drug discovery.

链霉菌属 SCSIO 03032 从来自印度洋的深海沉积物样本 (-3412 m) 中分离出来，产生几类生物活性化合物，包括α-吡啶酮抗生素（哌啶类）、多环大环内酰胺（heronamides）和双吲哚生物碱（spiroindimicins、indimicins 和 lynamicins ）。在这里，我们报告了Streptomyces sp的完整基因组序列。SCSIO 03032，由一条 6,287,975 bp 的线性染色体组成。基因组分析显示存在 29 个假定的次级代谢物生物合成基因簇，包括 piericidins、heronamides 和 spiroindimicins/indimicins/lynamicins。基因组序列表明链霉菌sp. SCSIO 03032 可能是新型生物活性天然产品的生产商，在药物发现中具有潜在应用。