This study aimed to investigate the immunomodulatory effects of walnut (Juglans regia L.) oligopeptides (WOPs). Female BALB/c mice were randomly assigned to control, whey protein control and three WOPs groups, given deionized water, 220 mg/kg BW whey protein, 110, 220 and 440 mg/kg BW WOPs daily through drinking water for 30 days, respectively. The immonomodulatory activity determination of WOPs involved innate and adaptive immunity, spleen T lymphocyte subpopulations, serum cytokine and immunoglobulin levels. Our results showed that WOPs could significantly improve humoral and cell-mediated immune responses, macrophage phagocytosis and natural killer cell activity. Moreover, increased T and Th cells percentages, cytokines secretion of interleukin (IL)-2, IL-10, IL-12 and granulocyte–macrophage colony stimulating factor, and production of immunoglobulin (Ig)A, IgG, IgM and intestinally secreted IgA also contributed to these improvements. All these above indicated that WOPs could be a promising immunomodulatory dietary supplement at dosages ranging from 110 to 440 mg/kg BW.

这项研究旨在研究核桃的免疫调节作用（核桃）L.）寡肽（WOP）。将雌性BALB / c小鼠随机分为对照组，乳清蛋白对照组和3个WOPs组，分别用去离子水，每天分别通过饮用水，连续30天分别给予220 mg / kg BW乳清蛋白，110、220和440 mg / kg BW WOPs。 。WOP的非调节活性测定涉及先天和适应性免疫，脾T淋巴细胞亚群，血清细胞因子和免疫球蛋白水平。我们的结果表明，WOP可以显着改善体液和细胞介导的免疫反应，巨噬细胞吞噬作用和自然杀伤细胞活性。此外，T和Th细胞百分比增加，白介素（IL）-2，IL-10，IL-12和粒细胞巨噬细胞集落刺激因子的细胞因子分泌以及免疫球蛋白（Ig）A，IgG，IgM和肠道分泌的IgA也有助于这些改善。以上所有这些表明，WOPs可能是一种有前途的免疫调节膳食补充剂，剂量范围为110至440 mg / kg BW。