As a veterinary antibiotic, lincomycin (LIN) residues in milk are raising concerns of public on account of potential harm to human health. Efficient strategy is eagerly desired for detection of LIN from milk samples. Hence, lincomycin molecularly imprinted membranes (LINMIMs) were developed for selective separation of LIN as an efficient pretreatment of milk samples. The synergistic effect of polyethylenimine and dopamine provided effective antifouling performance by improving the hydrophilicity. Based on click chemistry, specific recognition sites were facilely formed on membranes using 4-vinylpyridine as functional monomers. The satisfactory rebinding capacity (151.62 mg g⁻¹), permselectivity (4.43), together with the linear dependence (R² = 0.9902) of concentrations in eluents and original samples. Moreover, the method was utilized to determine LIN from milk, with good recovery and relative standard deviation. Achievements in this work will actively promote the development of efficient detection technology.

作为一种兽用抗生素，牛奶中的林可霉素（LIN）残留物可能对人体健康造成危害，引起了公众的关注。迫切需要一种有效的策略来检测牛奶样品中的LIN。因此，开发了林可霉素分子印迹膜（LINMIMs）以选择性分离LIN作为牛奶样品的有效预处理。聚乙烯亚胺和多巴胺的协同作用通过改善亲水性提供了有效的防污性能。基于点击化学，使用4-乙烯基吡啶作为功能单体在膜上容易地形成特异性识别位点。令人满意的重新结合能力（151.62 mg g ^-1），选择性渗透（4.43）以及线性依赖性（R ² = 0.9902）洗脱液和原始样品中的浓度。此外，该方法用于从牛奶中测定LIN，回收率和相对标准偏差均良好。这项工作的成果将积极促进高效检测技术的发展。