Aqueous coenzyme Q10 (CoQ10) dispersions were prepared using sugary maize dendrimer-like glucan (SMDG) with solid-dispersion treatment. After measuring solubility, recovery rate and loading rate, the initial weight ratio of CoQ10:SMDG was optimized to be 1:27, with the solubility markedly increasing up 188.8-folds compared to pure CoQ10 solution. The structural characterizations of CoQ10-SMDG formulation showed crystal CoQ10 was entrapped in SMDG matrix for amorphous state, associated with the strong interactions with glucan chains. The antioxidant activity of CoQ10-SMDG was assessed via DPPH and FRAP assay. DPPH scavenging activity and FRAP value of it were as high as 95.1% and 0.87 mM, respectively. The cellular uptake of CoQ10 in CoQ10-SMDG group was significantly higher than that of natural CoQ10. CoQ10-SMDG also exhibited significant protective effects against cellular damage in H₂O₂-induced HaCaT cell model. The results indicated that dendrimer-like glucan is an excellent platform to encapsulate and improve biological activity of hydropholic compounds.

辅酶Q10（CoQ10）水性分散液是使用含糖的玉米树状大分子样葡聚糖（SMDG）经过固体分散处理制备的。在测量溶解度，回收率和负载率后，将CoQ10：SMDG的初始重量比优化为1:27，与纯CoQ10溶液相比，溶解度显着提高了188.8倍。CoQ10-SMDG配方的结构特征表明，结晶CoQ10被困在SMDG基质中为非晶态，与葡聚糖链的强相互作用有关。通过DPPH和FRAP分析评估了CoQ10-SMDG的抗氧化活性。DPPH清除活性和FRAP值分别高达95.1％和0.87 mM。CoQ10-SMDG组的细胞对CoQ10的摄取显着高于天然CoQ10。₂ O ₂诱导的HaCaT细胞模型。结果表明，树状大分子样葡聚糖是封装和改善疏水性化合物生物活性的极佳平台。