The outcomes of refractive surgical procedures to improve uncorrected vision in patients—including photorefractive keratectomy (PRK), laser in-situ keratomileusis (LASIK), Small Incision Lenticule Extraction (SMILE) and corneal inlay procedures—is in large part determined by the corneal wound healing response after surgery. The wound healing response varies depending on the type of surgery, the level of intended correction of refractive error, the post-operative inflammatory response, generation of opacity producing myofibroblasts and likely poorly understood genetic factors. This article details what is known about these specific wound healing responses that include apoptosis of keratocytes and myofibroblasts, mitosis of corneal fibroblasts and myofibroblast precursors, the development of myofibroblasts from keratocyte-derived corneal fibroblasts and bone marrow-derived fibrocytes, deposition of disordered extracellular matrix by corneal fibroblasts and myofibroblasts, healing of the epithelial injury, and regeneration of the epithelial basement membrane. Problems with epithelial and stromal cellular viability and function that are altered by corneal inlays are also discussed. A better understanding of the wound healing response in refractive surgical procedures is likely to lead to better treatments to improve outcomes, limit complications of keratorefractive surgical procedures, and improve the safety and efficiency of refractive surgical procedures.

用于改善患者未矫正视力的屈光手术程序的结果——包括光屈光性角膜切除术 (PRK)、激光原位角膜磨镶术 (LASIK)、小切口透镜摘除术 (SMILE) 和角膜镶嵌手术——在很大程度上取决于角膜伤口手术后愈合反应。伤口愈合反应因手术类型、屈光不正的预期矫正水平、术后炎症反应、产生不透明的肌成纤维细胞和可能知之甚少的遗传因素而异。本文详细介绍了这些特定的伤口愈合反应，包括角膜细胞和肌成纤维细胞的凋亡、角膜成纤维细胞和肌成纤维细胞前体的有丝分裂，由角膜细胞来源的角膜成纤维细胞和骨髓来源的纤维细胞发育成肌成纤维细胞，角膜成纤维细胞和肌成纤维细胞沉积紊乱的细胞外基质，上皮损伤的愈合和上皮基底膜的再生。还讨论了角膜镶嵌改变的上皮和基质细胞活力和功能的问题。更好地了解屈光手术中的伤口愈合反应可能会导致更好的治疗，以改善结果，限制角膜屈光手术的并发症，并提高屈光手术的安全性和效率。和上皮基底膜的再生。还讨论了角膜镶嵌改变的上皮和基质细胞活力和功能的问题。更好地了解屈光手术中的伤口愈合反应可能会导致更好的治疗，以改善结果，限制角膜屈光手术的并发症，并提高屈光手术的安全性和效率。和上皮基底膜的再生。还讨论了角膜镶嵌改变的上皮和基质细胞活力和功能的问题。更好地了解屈光手术中的伤口愈合反应可能会导致更好的治疗，以改善结果，限制角膜屈光手术的并发症，并提高屈光手术的安全性和效率。