In chemodynamic therapy (CDT), novel chemodynamic reactions are urgently needed to promote the generating efficiency of reactive oxygen species (ROS), and meanwhile the real-time monitoring of ROS is really critical to minimize the toxic side effect of CDT. Herein, we develop a pH-responsive chemiluminescent and chemodynamic system (ultrathin Mn-oxides [MnOx] nanosheet - semiconducting polymer nanoparticles [SPNs]). We, for the first time, discover the capability of ultrathin MnOx nanosheets to generate ¹O₂ under the trigger of acidity. Notably, the ¹O₂ produced by MnOx can substitute light and specifically excite thiophene-based SPNs to emit photons for near-infrared chemiluminescent imaging, which greatly amplifies the generation of ¹O₂. Because of the intrinsic acidity within tumor, MnOx-SPNs realize the activatable chemodynamic therapy for solid tumor. Furthermore, the ratiometric chemiluminescent/fluorescent imaging is able to calibrate the output of ¹O₂ and achieve more accurate real-time and in situ monitoring of ¹O₂ production during therapy.

在化学动力疗法（CDT）中，迫切需要新颖的化学动力反应来提高活性氧（ROS）的产生效率，同时对ROS进行实时监测对于最大程度地降低CDT的毒副作用至关重要。在这里，我们开发了一种pH响应的化学发光和化学动力学系统（超分子Mn氧化物[MnOx]纳米片-半导体聚合物纳米颗粒[SPNs]）。我们第一次发现超薄MnOx纳米片在酸性触发下产生¹ O ₂的能力。值得注意的是¹ O ₂由MnOx产生的光可以替代光，并特别激发基于噻吩的SPN发出光子以用于近红外化学发光成像，这大大放大了¹ O ₂的产生。由于肿瘤内固有的酸性，MnOx-SPNs实现了针对实体瘤的可激活化学动力学疗法。此外，比例化学发光/荧光成像能够校准¹ O ₂的输出，并在治疗过程中实现对¹ O ₂产生量的更精确的实时和原位监测。