A novel uniform monodispersed radial mesoporous bioactive glass nanosphere (MBG) with high phosphorus and calcium content has been successfully synthesized. The synthesis was first taken place in a cyclohexane-water biphasic stratification reaction system, which fabricated the radial mesoporous SiO₂-P₂O₅ nanosphere (SPN) using hexadecyltrimethyl ammonium bromide (CTAB) as a template agent and triethanolamine (TEA) as a hydrolysis catalyst. Solid reactions were then carried out to synthesize SiO₂-CaO-P₂O₅ MBG using SPN as both the silicon source and phosphorus source, and Ca(NO₃)₂ as the calcium source. The prepared MBG not only displayed the radial structure and high specific surface area (~321 m²/g), but also had high phosphorus and calcium content. The results of energy dispersive spectrometer (EDS) demonstrated that P₂O₅ content was enhanced by properly increasing the reaction temperature. The in vitro bioactivity test showed that MBG had an excellent ability of inducing apatite formation. Furthermore, the MBG showed excellent biocompatibility at a low concentration of 50–100 μg/mL in vitro, and it would have a promising prospect as drug delivery system for bone tissue regeneration.

已经成功地合成了具有高磷和钙含量的新型均匀的单分散径向介孔生物活性玻璃纳米球（MBG）。合成首先在环己烷-水双相分层反应系统中进行，该系统以十六烷基三甲基溴化铵（CTAB）为模板剂，以三乙醇胺（TEA）为原料制备了径向介孔SiO ₂ -P ₂ O ₅纳米球（SPN）。水解催化剂。然后使用SPN作为硅源和磷源以及Ca（NO ₃）₂进行固相反应以合成SiO ₂ -CaO-P ₂ O ₅ MBG作为钙源。制备的MBG不仅显示出放射状结构和高比表面积（〜321 m ² / g），而且具有高的磷和钙含量。能量色散光谱仪（EDS）的结果表明，适当提高反应温度可提高P ₂ O ₅含量。体外生物活性测试表明，MBG具有极好的诱导磷灰石形成的能力。此外，MBG在低浓度50–100μg/ mL的体外显示出优异的生物相容性，作为骨组织再生的药物递送系统具有广阔的前景。