In this study, a polymeric drug delivery system based on chitosan and fish scale collagen was fabricated in the nanometer size by the emulsification method for loading lovastatin drug—a poorly water soluble drug for the treatment of reduction of cholesterol concentration in blood. An interesting point of this work is using collagen extracted from fresh water fish scales. The characteristics, properties, morphology and drug release control ability of the chitosan/collagen/lovastatin nanocomposites were evaluated by Infrared spectroscopy (IR), Field emission scanning electron microscopy (FESEM), Dynamic light scattering (DLS) and Ultraviolet–Visible spectroscopy (UV–Vis) methods. The obtained results showed that the chitosan/collagen/lovastatin nanocomposites are in spherical shape with the size of particles ranged from 72.1 to 444.0 nm. The chitosan/collagen system can improve the solubility and bioavailability of lovastatin in simulated gastric and intestine fluids. The drug release mechanism from chitosan/collagen/lovastatin nanocomposites was complied with the Korsmeyer-Peppas model. In addition, the in vivo test on mice of chitosan/collagen/lovastatin nanocomposites to investigate their toxicity was conducted and discussed.

Graphic Abstract

中文翻译：

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壳聚糖/鱼鳞胶原蛋白/洛伐他汀纳米复合材料的制备与表征

在这项研究中，通过乳化法制备了一种基于壳聚糖和鱼鳞状胶原蛋白的聚合物药物递送系统，以纳米级的尺寸装载洛伐他汀药物，该药物是一种水溶性差的药物，可降低血液中的胆固醇浓度。这项工作有趣的一点是使用从淡水鱼鳞中提取的胶原蛋白。通过红外光谱（IR），场发射扫描电子显微镜（FESEM），动态光散射（DLS）和紫外可见光谱（UV）评估了壳聚糖/胶原/洛伐他汀纳米复合材料的特性，性质，形态和药物释放控制能力。 –Vis）方法。所得结果表明，壳聚糖/胶原蛋白/洛伐他汀纳米复合材料为球形，颗粒尺寸为72.1至444.0nm。壳聚糖/胶原蛋白系统可以提高洛伐他汀在模拟胃液和肠液中的溶解度和生物利用度。壳聚糖/胶原蛋白/洛伐他汀纳米复合材料的释药机理符合Korsmeyer-Peppas模型。此外，进行了壳聚糖/胶原蛋白/洛伐他汀纳米复合材料小鼠体内试验，以研究其毒性。

图形摘要