Hypokinetic dysarthria is a multidimensional impairment affecting all main speech subsystems with variable patterns and severity across individual Parkinson's disease (PD) patients. We can thus assume that inter-individual abnormal speech patterns are related to the various clinical subtypes of PD with different prominent motor symptoms. The aim of this cross-sectional study was to compare speech disorder between patients with the postural instability/gait difficulty (PIGD) and tremor-dominant (TD) motor phenotypes of PD. Speech samples were acquired from a total of 63 participants, including 21 PIGD patients, 21 TD patients, and 21 healthy controls. Quantitative acoustic vocal assessment of 12 unique speech dimensions related to phonation, vocal tremor, oral diadochokinesis, articulation, prosody and speech timing was performed. Speech impairment was more pronounced in the PIGD group than in the TD group, with an area under the curve of 0.76. Patients in the PIGD group manifested abnormalities in pitch breaks, articulatory decay, decreased rate of follow-up speech segments and inappropriate silences, apart from monopitch and irregular AMR that were affected in TD group as well. An abnormal vocal tremor was present in only 10% of PD patients, with no differences between the PD phenotypes. We found a correlation between non-motor symptom severity and speech timing (r = − 0.40, p = 0.009). The present study demonstrates that speech disorder reflects the underlying motor phenotypes. Vocal tremor appeared to be an isolated phenomenon that does not share similar pathophysiology with limb tremor.

运动减退性构音障碍是一种多维损伤，影响个体帕金森病 (PD) 患者的所有主要语音子系统，其模式和严重程度各不相同。因此，我们可以假设个体间异常语音模式与具有不同突出运动症状的各种 PD 临床亚型有关。这项横断面研究的目的是比较姿势不稳/步态困难 (PIGD) 和震颤主导 (TD) 运动表型的 PD 患者之间的言语障碍。语音样本来自总共 63 名参与者，包括 21 名 PIGD 患者、21 名 TD 患者和 21 名健康对照者。对 12 个与发声、声带震颤、口腔强心运动、发音、韵律和语音计时相关的独特语音维度进行了定量声学语音评估。PIGD 组的言语障碍比 TD 组更明显，曲线下面积为 0.76。除了TD组的单音节和不规则的AMR外，PIGD组的患者还表现出音调中断、发音衰减、后续语音片段率下降和不适当的沉默等异常。只有 10% 的 PD 患者存在异常声带震颤，PD 表型之间没有差异。我们发现非运动症状严重程度与说话时间之间存在相关性（除了单节距和不规则 AMR 在 TD 组中也受到影响。只有 10% 的 PD 患者存在异常声带震颤，PD 表型之间没有差异。我们发现非运动症状严重程度与说话时间之间存在相关性（除了单节距和不规则 AMR 在 TD 组中也受到影响。只有 10% 的 PD 患者存在异常声带震颤，PD 表型之间没有差异。我们发现非运动症状严重程度与说话时间之间存在相关性（r  = − 0.40，p  = 0.009）。本研究表明言语障碍反映了潜在的运动表型。声音震颤似乎是一种孤立的现象，与肢体震颤的病理生理学不同。