Adjuvant activity of fucoidans in experimental vaccine compositions with ovalbumin was studied on a mouse model. Compositions with sulfated polysaccharides from brown alga Fucus evanescens (native fucoidan in combination with polyphenols, and a product of fucoidan enzymatic hydrolysis) induced multiple productions of antigen-specific antibodies — total IgG, its isotypes IgG1 and, especially, IgG2a, in comparison with an individual ovalbumin. The adjuvant effect of native and structurally modified fucoidans is slightly inferior to that of the traditional licensed aluminum hydroxide adjuvant. The results indicate the prospects of using sulfated polysaccharides from F. evanescens as adjuvants in vaccines.

中文翻译：

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海洋水生物硫酸化多糖对小鼠卵清蛋白体液免疫反应的影响


在小鼠模型上研究了含有卵清蛋白的实验疫苗组合物中岩藻依聚糖的佐剂活性。与来自褐藻的硫酸化多糖组合物（天然岩藻依聚糖与多酚的组合，以及岩藻依聚糖酶水解的产物）的组合物诱导多种抗原特异性抗体的产生——总IgG、其同种型IgG1，尤其是IgG2a，与个体卵清蛋白。天然和结构修饰的岩藻依聚糖的佐剂效果略逊于传统许可的氢氧化铝佐剂。这些结果表明了使用来自 F. evanescens 的硫酸化多糖作为疫苗佐剂的前景。