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Dopamine Improves Resistance of Dendrites of Mauthner Neurons to Destruction Induced by Sensory Stimulation and Application of Β-Amyloid
Bulletin of Experimental Biology and Medicine ( IF 0.9 ) Pub Date : 2020-06-01 , DOI: 10.1007/s10517-020-04865-y
N R Tiras 1 , I B Mikheeva 1 , G Z Mikhailova 1 , N A Pen'kova 1 , S S Khutsyan 1
Affiliation  

Mauthner neurons in goldfish fry were studied by the methods of light and electron microscopy. The structure and volume of individual dendrites as well as the structure of axodendritic synapses were examined using virtual images of neurons formed from serial 3-μ sections. In short-time (5 h) experiments with application of dopamine, β-amyloid fragment (25-35), and long-term sensory stimulation affecting afferent inputs to Mauthner neurons, the dendrites were larger than the same dendrites under the same conditions without dopamine application. Application of dopamine induced no pathological changes in the structure of axodendritic chemical and electric synapses containing desmosome-like contacts.

中文翻译:

多巴胺提高 Mauthner 神经元树突对感官刺激和 β-淀粉样蛋白应用引起的破坏的抵抗力

采用光学和电子显微镜方法研究了金鱼鱼苗中的Mauthner神经元。使用由连续 3-μ 切片形成的神经元的虚拟图像检查单个树突的结构和体积以及轴树突突触的结构。在应用多巴胺、β-淀粉样蛋白片段 (25-35) 和长期感觉刺激影响 Mauthner 神经元传入输入的短时间 (5 h) 实验中,在相同条件下,树突比相同的树突大多巴胺应用。多巴胺的应用未引起含有桥粒样接触的轴树突化学和电突触的结构发生病理变化。
更新日期:2020-06-01
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