This pilot study was aimed at evaluation of the translational potential of xenon as a potential antidepressant. In placebo-controlled double-blind study, 14 healthy right-handed volunteers were randomly assigned to 15-min inhalation session of either gas mixture with xenon (25%Хе/30%О 2 /45%N 2 ) or placebo (70%N 2 /30%О 2 ) with simultaneous recording of 64-channel EEG. To assess the dynamics and nature of emotional activation in response to xenon and placebo, we analyzed both the intensity of positive and negative emotions and individual alpha peak frequency (iAPF) of EEG. We found that xenon in sub-anesthetic doses promoted positive emotional arousal, and that emotional response to xenon depended on individual neurophysiological endophenotype of alpha-activity (iAPF). The authors suggest that iAPF shifts can be used as a neurophysiological predictor of individual thymoleptic response to xenon.

中文翻译：

---

氙对人体胸腺刺激作用的心理生理学分析

这项初步研究旨在评估氙作为潜在抗抑郁药的转化潜力。在安慰剂对照的双盲研究中，14 名健康的右手志愿者被随机分配接受 15 分钟的氙气混合气体（25%Хе/30%О 2 /45%N 2 ）或安慰剂（70% N 2 /30%О 2 ) 同时记录 64 通道 EEG。为了评估响应氙气和安慰剂的情绪激活的动力学和性质，我们分析了积极和消极情绪的强度以及 EEG 的个体 α 峰值频率 (iAPF)。我们发现亚麻醉剂量的氙气促进了积极的情绪唤醒，对氙气的情绪反应取决于个体的 α 活性 (iAPF) 神经生理内表型。