We studied the effect of tripeptide Leu-Ile-Lys on the course of chronic 16-week oxalate nephrolithiasis in rats modeled by administration of 1% ethylene glycol solution in drinking water for 16 weeks. The tripeptide Leu-Ile-Lys obtained by chemical synthesis (sample purity ≥98%) was administered intragastrically through a probe in a dose of 11.5 mg/kg in 1 ml saline. It was found that during tripeptide Leu-Ile-Lys significantly alleviated the course of experimental pathology, which was confirmed by characteristic biochemical and morphological indicators. We observed a decrease in the concentration of calcium ions by 4.4 times, weakening of oxidative stress in the renal tissue due to a decrease in the total prooxidant activity by 1.2 times, normalization of increased catalase activity, and reduction of superoxide dismutase activity by 2.4 times relative to disease control. Histological signs of nephrolithiasis were recorded in 9% cases ( vs . 75% cases in disease control).

中文翻译：

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三肽Leu-Ile-Lys用于大鼠慢性16周草酸盐肾结石实验性治疗的经验

我们研究了三肽 Leu-Ile-Lys 对大鼠慢性 16 周草酸盐肾结石病程的影响，该大鼠通过在饮用水中施用 1% 乙二醇溶液 16 周进行建模。通过化学合成获得的三肽 Leu-Ile-Lys（样品纯度≥98%）通过探针以 11.5 mg/kg 的剂量在 1 ml 盐水中灌胃给药。发现在三肽Leu-Ile-Lys期间显着减轻了实验病理过程，这通过特征生化和形态学指标得到证实。我们观察到钙离子浓度降低了 4.4 倍，由于总促氧化活性降低了 1.2 倍，肾组织中的氧化应激减弱，过氧化氢酶活性增加正常化，超氧化物歧化酶活性降低了 2。4倍相对于疾病控制。在 9% 的病例中记录了肾结石的组织学体征（疾病控制中为 75%）。