The peculiarities of implication of NMDA glutamate receptors and protein synthesis into the mechanisms responsible for impairment of memory reconsolidation were studied in edible snails conditioned to food aversion. Injections of NMDA glutamate receptor antagonists or protein synthesis inhibitor prior to reminding with conditioned food stimulus provoked development of amnesia after different latent periods. NMDA glutamate receptor antagonists gradually weakened the aversive reactions to conditioned stimulus presented in parallel with reminder during 1 h. The protein synthesis inhibitor cycloheximide provoked the development of amnesia only 2.5 h after the onset of reminding procedure. Combined injections of protein synthesis inhibitor and NMDA glutamate receptor antagonist prior to reminding completely prevented the development of amnesia. The data agree with hypothesis that memory reconsolidation and amnesia are distinct processes, which need activation of synthesis of specific proteins.

中文翻译：

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与记忆再巩固和遗忘症诱导有关的蛋白质合成的特殊性

在厌食的可食用蜗牛中研究了 NMDA 谷氨酸受体和蛋白质合成对记忆再巩固受损机制的影响的特殊性。在用条件性食物刺激提醒之前注射 NMDA 谷氨酸受体拮抗剂或蛋白质合成抑制剂会在不同的潜伏期后引发健忘症的发展。NMDA 谷氨酸受体拮抗剂在 1 小时内逐渐减弱对与提醒同时出现的条件刺激的厌恶反应。蛋白质合成抑制剂放线菌酮在提醒程序开始后仅 2.5 小时就引发了健忘症的发展。提醒前联合注射蛋白质合成抑制剂和NMDA谷氨酸受体拮抗剂完全防止了健忘症的发展。