Effects of polysiloxanes with different molecular weights on in vitro cytotoxicity and properties of polyurethane/cotton–cellulose nanofiber nanocomposite films,Polymer Chemistry

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Effects of polysiloxanes with different molecular weights on in vitro cytotoxicity and properties of polyurethane/cotton–cellulose nanofiber nanocomposite films
Polymer Chemistry ( IF 4.1 ) Pub Date : 2020-07-09 , DOI: 10.1039/d0py00809e
Chang-An Xu _{1,

2,

3,

4,

5} , Bingfei Nan _{1,

2,

3,

4,

5} , Mangeng Lu _{1,

2,

3,

4,

5} , Zhencai Qu _{1,

2,

3,

4,

5} , Zhiyou Tan _{1,

2,

3,

4,

5} , Kun Wu _{1,

2,

3,

4,

5} , Jun Shi _{1,

2,

3,

4,

5}

Affiliation

A series of polyurethane/cotton–cellulose nanofiber nanocomposite films are manufactured using amino-terminated polydimethylsiloxane (H₂N-PDMS-NH₂), polycarbonate diol (PCDL), isophorone diisocyanate (IPDI), and dispersed cotton–cellulose nanofibers (c-CNF). The heat resistance, hydrophobicity, mechanical properties, surface morphology and effect on cells of the film are studied. The results show that as the molecular weight of H₂N-PDMS-NH₂ increases, the heat resistance and hydrophobicity of the material improve, and when the molecular weight is 4000, its surface free energy reaches 14.9 mJ m⁻². This is mainly because an increase in the molecular weight of H₂N-PDMS-NH₂ changes the chemical structure of the polymer and increases the possibility of low surface energy Si enrichment on the surface. In addition, the cell viability reaches 78.31% in the MTT experiment, which may be related to the biocompatibility of H₂N-PDMS-NH₂. The relative hemolysis rate of the polymer material to red blood cells is less than 2%, and also shows lower adhesion to platelet cells, which may be related to the hydrophobicity of the surface.

中文翻译：

不同分子量的聚硅氧烷对聚氨酯/棉纤维素纳米纤维纳米复合薄膜体外细胞毒性和性能的影响

使用氨基封端的聚二甲基硅氧烷（H ₂ N-PDMS-NH ₂），聚碳酸酯二醇（PCDL），异佛尔酮二异氰酸酯（IPDI）和分散的棉-纤维素纳米纤维（c- CNF）。研究了耐热性，疏水性，机械性能，表面形态以及对薄膜细胞的影响。结果表明，随着H ₂ N-PDMS-NH ₂分子量的增加，材料的耐热性和疏水性提高，当分子量为4000时，其表面自由能达到14.9 mJ m ^-2。这主要是因为H ₂ N-PDMS-NH ₂的分子量增加改变了聚合物的化学结构，增加了表面能低的Si富集的可能性。另外，MTT实验中细胞活力达到78.31％，这可能与H ₂ N-PDMS-NH ₂的生物相容性有关。聚合物材料对红细胞的相对溶血率小于2％，并且还显示出与血小板细胞的较低粘附性，这可能与表面的疏水性有关。

更新日期：2020-08-18

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