In population-based studies, the genetic variability of the APOE E alleles have been associated with health outcomes. Health problems are common in subjects with obesity. This study explored associations between the APOE E alleles and comorbidity in subjects with morbid obesity. The study included consecutive subjects referred for evaluation of bariatric surgery with morbid obesity (defined as BMI > 40 or > 35 kg/m2 with complications related to obesity). The subjects followed a conservative weight loss program for 6 months before surgery and had a follow-up visit 12 months after surgery. Demographic data and a set psychosomatic scores (musculoskeletal pain, WHO-5 Well-Being Index, Rosenberg Self-Esteem Scale, Hopkins Symptom Check-list 10; Epworth Sleepiness Scale, and Fatigue Severity Scale) were collected, and blood samples were analysed for haematological and biochemical parameters and APOE alleles. One hundred and forty subjects (men/women: 32 (23%)/108 (77%) with mean age 43.0 (SD 8.7) years and BMI 42.1 (SD 3.8) kg/m2 were included. One hundred and eight and 92 subjects had data after conservative treatment and 12 months after surgery, respectively. The prevalence of the APOE alleles were: E2E2: 1 (0.7%), E2E3: 13 (9.3%), E2E4: 4 (2.9%), E3E3: 71 (50.7%), E3E4: 47 (33.6%), and E4E4: 4 (2.9%). The prevalence rates were as anticipated in a Norwegian population. The weight loss during conservative treatment and after bariatric surgery was independent of E allele variability. E2 was associated with a significant or clear trend toward improvement of all psychosomatic disorders. There was a significant fall in CRP during the two treatment periods with weight loss. E2 and E4 were significantly associated with high and low CRP, respectively, but no associations were seen between CRP and comorbidity. The most marked finding was the association between E2 and improvement of all psychosomatic disorders. The positive and negative associations between CRP and E2 and E4, respectively, could indicate effects on inflammation and immunological reactions.

中文翻译：

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APOE-病态肥胖患者合并症的遗传标记。

在基于人群的研究中，APOE E等位基因的遗传变异与健康状况相关。肥胖患者常见健康问题。这项研究探讨了APOE E等位基因与合并症的合并症之间的关联。该研究包括连续的病患肥胖症（定义为BMI> 40或> 35 kg / m2，并伴有肥胖症并发症）的减肥手术评估对象。受试者在手术前进行了6个月的保守减肥计划，并在手术后12个月进行了随访。收集了人口统计学数据和一组心身评分（肌肉骨骼疼痛，WHO-5健康指数，Rosenberg自尊量表，霍普金斯症状检查表10； Epworth困倦量表和疲劳严重程度表），并分析血液样本的血液学和生化参数以及APOE等位基因。包括140名受试者（男性/女性：32（23％）/ 108（77％），平均年龄43.0（SD 8.7）岁和BMI 42.1（SD 3.8）kg /m2。108名和92名受试者分别在保守治疗和术后12个月获得了数据，APOE等位基因的患病率分别为：E2E2：1（0.7％），E2E3：13（9.3％），E2E4：4（2.9％），E3E3：71（50.7 ％），E3E4：47（33.6％）和E4E4：4（2.9％），患病率符合挪威人群的预期，在保守治疗期间和减肥手术后体重减轻与E等位基因变异无关。与所有心身疾病改善的明显或明显趋势相关。在两个治疗期间，随着体重减轻，CRP显着下降。E2和E4分别与高和低CRP显着相关，但在CRP和合并症之间没有关联。最明显的发现是E2与所有心身疾病改善之间的关联。CRP与E2和E4之间的正向和负向联系可能表明对炎症和免疫反应有影响。