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General Method for Quantitation of Organic Hydroperoxides
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2020-07-09 , DOI: 10.1021/acs.oprd.0c00251
Gregory L. Beutner 1 , Sloan Ayers 1 , Tao Chen 2 , Simon W. Leung 1 , Hua Chia Tai 1 , Qinggang Wang 1
Affiliation  

The utility of peroxides in synthetic organic chemistry is tied to significant safety risks posed by their handling, storage, and disposal. Although guidelines exist, a lack of reliable methods for quantitation of low levels of these species has been a major impediment to establishing data-driven safety guidelines and protocols. This paper discloses a general and reliable liquid chromatography-ultraviolet (LC-UV)-based method for the detection of a wide range of commonly encountered organic hydroperoxides. The implications of this method for safety concerns around trace peroxides are also discussed, supported by modern thermochemical analysis.

中文翻译:

定量有机氢过氧化物的通用方法

过氧化物在合成有机化学中的用途与它们的处理,储存和处置带来的重大安全风险有关。尽管存在指导原则,但缺乏可靠的方法来定量分析这些物种的低含量一直是建立以数据为依据的安全指导原则和协议的主要障碍。本文公开了一种基于常规且可靠的液相色谱-紫外线(LC-UV)的方法,用于检测各种常见的有机氢过氧化物。在现代热化学分析的支持下,还讨论了该方法对痕量过氧化物的安全性隐患。
更新日期:2020-07-17
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