Background. Female adolescents are considered a risk group for cardiometabolic disease due to their lifestyle (LS). Objective. To evaluate the association between LS classes and body composition groups with cardiometabolic disease risk factors and pro- and anti-inflammatory biomarkers in female adolescents. Methods. This cross-sectional study was carried out with female adolescents aged 14 to 19 years, from Viçosa-MG, Brazil. Latent class analysis assessed LS classes. Kinanthropometric measurements were taken together with the body fat percentage (BF%), being analyzed by the Dual Energy X-ray Absorptiometry (DEXA) equipment. Blood pressure and biochemical parameters were analyzed in the Health Division of the Federal University of Viçosa. The pro- and anti-inflammatory biomarkers were analyzed using Luminex technology. Associations with biomarkers were estimated by multiple linear regression. Results. 405 female adolescents were evaluated. The majority, 82.57%, 72.90%, and 65.31%, were classified as inactive by the number of steps, with high screen and cell phone time, respectively. Furthermore, 41.55% did meet the minimum of 60 minutes of moderate-to-vigorous physical activity (MVPA) and 54.69% had high values of BF% (DEXA). The “Sedentary & Inactive LS” class together with the high levels of weight and BF% were associated with increased levels of blood pressure, lipid profile, and uric acid. It was also found that “Inactive & Sedentary LS”, high BF%, insulin resistance, and ultra-sensitive C-reactive protein were associated with the concentrations of proinflammatory biomarkers of tumor necrosis factor-α, interleukin-6, and leptin. Conclusion. We concluded that female adolescents with overweight/obese and high BF% presented higher values of anthropometric indicators, levels of blood pressure, concentration of uric acid and hs-CRP, and lower concentration of HDL. Inactive and Sedentary lifestyle of these girls, along with excess body fat, insulin resistance, and higher concentrations of hs-CRP were associated with the higher concentration proinflammatory markers.

中文翻译：

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生活方式和身体成分与青少年女性心血管代谢疾病和生物标志物危险因素的关联。


背景。由于生活方式（LS），女性青少年被认为是心脏代谢疾病的高危人群。客观的。评估女性青少年 LS 等级和身体成分组与心脏代谢疾病危险因素以及促炎和抗炎生物标志物之间的关联。方法。这项横断面研究针对来自巴西 Viçosa-MG 的 14 至 19 岁女性青少年进行。潜在类别分析评估了 LS 类别。人体运动测量与体脂百分比 (BF%) 一起进行，并通过双能 X 射线吸收测量 (DEXA) 设备进行分析。维索萨联邦大学健康部门对血压和生化参数进行了分析。使用 Luminex 技术分析促炎和抗炎生物标志物。通过多元线性回归估计与生物标志物的关联。结果。 405 名女性青少年接受了评估。大部分人（82.57%、72.90% 和 65.31%）按步数、看屏幕时间和玩手机时间较长的情况被归类为不活跃。此外，41.55% 的人确实达到了 60 分钟中度至剧烈体力活动 (MVPA) 的最低要求，54.69% 的人具有较高的 BF% (DEXA) 值。 “久坐和不活动的 LS”类别以及高水平的体重和 BF% 与血压、血脂和尿酸水平升高相关。研究还发现，“不活动和久坐的 LS”、高 BF%、胰岛素抵抗和超敏感 C 反应蛋白与肿瘤坏死因子-α 、白介素-6 和瘦素等促炎生物标志物的浓度相关。结论。 我们得出的结论是，超重/肥胖和高BF%的女性青少年的人体测量指标、血压水平、尿酸和hs-CRP浓度较高，而HDL浓度较低。这些女孩的不活跃和久坐的生活方式，以及过多的体脂、胰岛素抵抗和较高浓度的 hs-CRP 与较高浓度的促炎标记物相关。