Base excision repair (BER), consisting mostly of lesion-specific DNA glycosylases and apurinic/apyrimidinic (AP) endonucleases, is one of the most important DNA repair mechanisms for repair of single nucleobase lesions generated by reactive oxygen and nitrogen species as part of an immune response against bacterial infections. However, few studies have addressed the contribution of BER to bacterial virulence and Listeria monocytogenes BER has thus far remained completely uncharacterized.

中文翻译：

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碱基切除修复在感染期间单核细胞增生李斯特菌 DNA 应激存活中的作用。

碱基切除修复 (BER) 主要由病变特异性 DNA 糖基化酶和无嘌呤/无嘧啶 (AP) 核酸内切酶组成，是修复由活性氧和氮物种产生的单个核碱基损伤的最重要的 DNA 修复机制之一对细菌感染的免疫反应。然而，很少有研究涉及 BER 对细菌毒力的影响，而单核细胞增生李斯特菌BER 迄今仍未完全确定特征。