Abstract

For patients with COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the damages to multiple organs have been clinically observed. Since most of current investigations for virus–host interaction are based on cell level, there is an urgent demand to probe tissue-specific features associated with SARS-CoV-2 infection. Based on collected proteomic datasets from human lung, colon, kidney, liver, and heart, we constructed a virus-receptor network, a virus-interaction network, and a virus-perturbation network. In the tissue-specific networks associated with virus–host crosstalk, both common and different key hubs are revealed in diverse tissues. Ubiquitous hubs in multiple tissues such as BRD4 and RIPK1 would be promising drug targets to rescue multi-organ injury and deal with inflammation. Certain tissue-unique hubs such as REEP5 might mediate specific olfactory dysfunction. The present analysis implies that SARS-CoV-2 could affect multi-targets in diverse host tissues, and the treatment of COVID-19 would be a complex task.

中文翻译：

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蛋白质组学数据分析揭示了与SARS-CoV-2感染相关的组织特异性网络

抽象的

对于由严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2）引起的COVID-19患者，已经在临床上观察到了对多个器官的损害。由于当前对病毒与宿主相互作用的大多数研究都基于细胞水平，因此迫切需要探索与SARS-CoV-2感染相关的组织特定特征。基于从人的肺，结肠，肾脏，肝脏和心脏收集的蛋白质组数据集，我们构建了病毒受体网络，病毒相互作用网络和病毒扰动网络。在与病毒-宿主串扰相关的特定于组织的网络中，不同组织揭示了共同的和不同的关键枢纽。BRD4和RIPK1等多种组织中普遍存在的集线器将有望成为抢救多器官损伤并应对炎症的药物靶标。某些组织独特的集线器（例如REEP5）可能介导特定的嗅觉功能障碍。目前的分析表明，SARS-CoV-2可能影响多种宿主组织中的多个靶标，而COVID-19的治疗将是一项复杂的任务。