Here, the authors present a novel solid-state nanopore device, fabricated by a transfer of a nanopore device to a dielectric polydimethylsiloxane (PDMS) microchannel-guided structure, and investigate the characteristics of DNA translocation through the nanopore. Apart from the extremely low noise level exhibited by this device on a highly insulating and low dielectric PDMS microchannel, this device also shows a slow translocation speed of 48 kbp Lambda DNA (λ-DNA), with a reduction of more than one order of magnitude than that in previously reported results on SiNx nanopores. The authors propose that the electrostatic interaction between the PDMS microchannel and DNA, resulting from the hydrophobicity of both PDMS and DNA, provides an additional attraction force that slows down DNA translocation. Such advanced solid-state nanopore devices can be utilized in various fields, including DNA or protein sequencing, drug screening, and microRNA detection.

中文翻译：

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通过应用疏水性微通道引导的壁来减慢DNA通过固态纳米孔的转运

在这里，作者提出了一种新颖的固态纳米孔器件，该器件是通过将纳米孔器件转移到介电聚二甲基硅氧烷（PDMS）微通道引导的结构而制成的，并研究了通过纳米孔进行DNA转运的特性。除了该设备在高度绝缘和低介电的PDMS微通道上表现出的极低噪声水平外，该设备还显示出48 kbp Lambda DNA（λ-DNA）的慢速迁移速度，降低幅度超过一个数量级。比以前报道的有关SiNx纳米孔的结果要好。作者认为，PDMS微通道和DNA之间的静电相互作用是由PDMS和DNA的疏水性引起的，提供了额外的吸引力，从而降低了DNA的转运速度。