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Reward Contributions to Serotonergic Functions.
Annual Review of Neuroscience ( IF 12.1 ) Pub Date : 2020-07-08 , DOI: 10.1146/annurev-neuro-093019-112252
Zhixiang Liu 1 , Rui Lin 1 , Minmin Luo 1, 2, 3
Affiliation  

The brain serotonin systems participate in numerous aspects of reward processing, although it remains elusive how exactly serotonin signals regulate neural computation and reward-related behavior. The application of optogenetics and imaging techniques during the last decade has provided many insights. Here, we review recent progress on the organization and physiology of the dorsal raphe serotonin neurons and the relationships between their activity and behavioral functions in the context of reward processing. We also discuss several interesting theories on serotonin's function and how these theories may be reconciled by the possibility that serotonin, acting in synergy with coreleased glutamate, tracks and calculates the so-called beneficialness of the current state to guide an animal's behavior in dynamic environments.

中文翻译:


奖励对血清素功能的贡献。

大脑血清素系统参与奖励处理的许多方面,尽管尚不清楚血清素信号究竟如何调节神经计算和奖励相关行为。过去十年中光遗传学和成像技术的应用提供了许多见解。在这里,我们回顾了中缝背侧血清素神经元的组织和生理学的最新进展,以及它们在奖励处理背景下的活动和行为功能之间的关系。我们还讨论了一些关于 5-羟色胺功能的有趣理论,以及这些理论如何与 5-羟色胺与共同释放的谷氨酸协同作用,跟踪和计算当前状态的所谓有益性以指导动物在动态环境中的行为的可能性相协调。

更新日期:2020-07-09
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