Metadynamics of Paths.,Physical Review Letters

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Metadynamics of Paths.
Physical Review Letters ( IF 8.1 ) Pub Date : 2020-07-09 , DOI: 10.1103/physrevlett.125.026001
Davide Mandelli ₁ , Barak Hirshberg _{2,

3} , Michele Parrinello _{1,

2,

3}

Affiliation

We present a method to sample reactive pathways via biased molecular dynamics simulations in trajectory space. We show that the use of enhanced sampling techniques enables unconstrained exploration of multiple reaction routes. Time correlation functions are conveniently computed via reweighted averages along a single trajectory and kinetic rates are accessed at no additional cost. These abilities are illustrated analyzing a model potential and the umbrella inversion of