Abstract

We propose here that one of the potential mechanisms for the relapse of the COVID-19 infection could be a cellular transport pathway associated with the release of the SARS-CoV-2-loaded exosomes and other extracellular vesicles. It is possible that this “Trojan horse” strategy represents possible explanation for the re-appearance of the viral RNA in the recovered COVID-19 patients 7–14 day post discharge, suggesting that viral material was hidden within such exosomes or extracellular vesicles during this “silence” time period and then started to re-spread again.

Communicated by Ramaswamy H. Sarma

中文翻译：

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关于外泌体在 COVID-19 再感染/再激活机会中的潜在作用

摘要

我们在此提出，COVID-19 感染复发的潜在机制之一可能是与 SARS-CoV-2 负载的外泌体和其他细胞外囊泡的释放相关的细胞运输途径。这种“特洛伊木马”策略可能代表了出院后 7-14 天康复的 COVID-19 患者中病毒 RNA 重新出现的可能解释，表明在此期间病毒物质隐藏在此类外泌体或细胞外囊泡中。 “沉默”的时间段，然后又开始重新蔓延。

由 Ramaswamy H. Sarma 交流