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Protein extracts from Momordica charantia var. charantia and M. charantia var. muricata show anti-lipidemic and antioxidant properties in experimental type 2 diabetic rats.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-07-09 , DOI: 10.1111/jfbc.13370 Sundar Poovitha 1 , Madasamy Parani 1
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-07-09 , DOI: 10.1111/jfbc.13370 Sundar Poovitha 1 , Madasamy Parani 1
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Plant‐derived compounds are used to manage dyslipidemia and oxidative stress in type 2 diabetic condition. In this study, anti‐lipidemic and antioxidant properties of the protein extracts from “Charantia” (PEC) and “Muricata” (PEM) varieties of Momordica charantia were analyzed by quantifying lipids, hepatic, renal, and oxidative stress markers, and histopathological examination of liver and kidney tissues. Protein extracts were orally administered at 10 (PEC10, PEM10) or 20 mg/kg body weight (PEC20, PEM20). Levels of cholesterol, low‐density lipoprotein, and triglycerides decreased but high‐density lipoprotein increased significantly in treated rats as compared to untreated diabetic rats (p < .01), and attained normal physiological range in both doses. Levels of superoxide dismutase, catalase, glutathione peroxidase, and reduced glutathione increased but thiobarbituric acid reactive substances decreased significantly in treated rats as compared to untreated diabetic rats (p < .01), and attained normal physiological range in PEM20 only. Histopathological examinations supported a protective role for the protein extracts against oxidative stress.
中文翻译：
苦瓜变种的蛋白质提取物。charantia和M.charantia var。muricata在实验性2型糖尿病大鼠中显示出抗血脂和抗氧化特性。
植物衍生的化合物用于控制2型糖尿病患者的血脂异常和氧化应激。在这项研究中，通过定量脂质，肝，肾和氧化应激标记物以及组织病理学检查分析了苦瓜属的“ Charantia”（PEC）和“ Muricata”（PEM）变种的蛋白质提取物的抗血脂和抗氧化特性。肝和肾组织。蛋白质提取物以10（PEC10，PEM10）或20 mg / kg体重（PEC20，PEM20）口服给药。与未治疗的糖尿病大鼠相比，治疗的大鼠中胆固醇，低密度脂蛋白和甘油三酸酯的水平降低，但高密度脂蛋白显着增加（p <.01），并且两个剂量均达到正常的生理范围。与未经治疗的糖尿病大鼠相比，经治疗的大鼠中超氧化物歧化酶，过氧化氢酶，谷胱甘肽过氧化物酶和还原型谷胱甘肽的水平升高，但硫代巴比妥酸反应性物质显着降低（p <.01），仅在PEM20中达到正常生理范围。组织病理学检查支持蛋白质提取物抵抗氧化应激的保护作用。
更新日期：2020-09-14
中文翻译：
苦瓜变种的蛋白质提取物。charantia和M.charantia var。muricata在实验性2型糖尿病大鼠中显示出抗血脂和抗氧化特性。
植物衍生的化合物用于控制2型糖尿病患者的血脂异常和氧化应激。在这项研究中，通过定量脂质，肝，肾和氧化应激标记物以及组织病理学检查分析了苦瓜属的“ Charantia”（PEC）和“ Muricata”（PEM）变种的蛋白质提取物的抗血脂和抗氧化特性。肝和肾组织。蛋白质提取物以10（PEC10，PEM10）或20 mg / kg体重（PEC20，PEM20）口服给药。与未治疗的糖尿病大鼠相比，治疗的大鼠中胆固醇，低密度脂蛋白和甘油三酸酯的水平降低，但高密度脂蛋白显着增加（p <.01），并且两个剂量均达到正常的生理范围。与未经治疗的糖尿病大鼠相比，经治疗的大鼠中超氧化物歧化酶，过氧化氢酶，谷胱甘肽过氧化物酶和还原型谷胱甘肽的水平升高，但硫代巴比妥酸反应性物质显着降低（p <.01），仅在PEM20中达到正常生理范围。组织病理学检查支持蛋白质提取物抵抗氧化应激的保护作用。
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