Lanostane-type triterpenoids from Ganoderma applanatum and their inhibitory activities on NO production in LPS-induced BV-2 cells,Phytochemistry

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Lanostane-type triterpenoids from Ganoderma applanatum and their inhibitory activities on NO production in LPS-induced BV-2 cells
Phytochemistry ( IF 3.2 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.phytochem.2020.112453
Di Luo ₁ , Ji-Zhao Xie ₁ , Lu-Hui Zou ₁ , Li Qiu ₁ , Dong-Ping Huang ₂ , Yun-Feng Xie ₁ , Huan-Ji Xu ₁ , Xin-Duo Wu ₁

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Five previously undescribed lanostane-type triterpenoids, including two triterpenoids with a rearranged side chain (applanoic acids E and F), one C21 nortriterpenoid (16,17-dehydroapplanone E), as well as two highly oxygenated lanostane triterpenoids (methyl applaniate B and applanoic acid G), were isolated from the fruiting bodies of Ganoderma applanatum (Pers.) Pat. Their structures were elucidated on the basis of spectroscopic analysis, X-ray crystallography and ECD data. Applanoic acid E, 16,17-dehydroapplanone E, and methyl applaniate B showed inhibitory effects on the release of NO by LPS-induced BV-2 cells.

中文翻译：

来自灵芝的羊毛甾烷型三萜类化合物及其对 LPS 诱导的 BV-2 细胞中 NO 产生的抑制作用

五种以前未描述过的羊毛脂烷型三萜，包括两种具有重排侧链的三萜（扁平酸 E 和 F）、一种 C21 去甲三萜（16,17-脱氢扁平酮 E），以及两种高度氧化的羊毛脂三萜（甲基扁平 B 和 applanoic酸 G)，是从 Ganoderma applanatum (Pers.) Pat. 的子实体中分离出来的。基于光谱分析、X 射线晶体学和 ECD 数据阐明了它们的结构。Applanoic acid E、16,17-dehydroapplanone E 和methylapplanate B 对LPS 诱导的BV-2 细胞释放NO 有抑制作用。

更新日期：2020-09-01

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