In this study, the modified sol-gel derived Bioactive glasses (BGs) in 60% SiO₂-(36-X)% CaO-4% P₂O₅-X% ZrO₂ (which X = 0, 5 and 10 mol.%) quaternary system were synthesized. Structural and morphological analyses were performed by Fourier transform infrared spectrum (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD) analysis. Afterwards, the compressive strength of synthesized BGs was evaluated. Moreover, 3-(4, 5dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay, alkaline phosphatase (ALP) activity, and antibacterial studies were taken to prove that how the values of proliferation and differentiation of MC3T3-E1 cells were changed by the addition of Zr. Results revealed a significant increase of antibacterial percentage in BG-5Zr in comparison to other BGs. The concentration of various ions and variation of pH values were measured by inductively coupled plasma atomic emission spectroscopy (ICP-AES) and pH meter. Taken together, investigations led to suggest BG-5Zr as a high potential specimen for clinical application.

在这项研究中，改性的溶胶-凝胶衍生的生物活性玻璃（BG）在60％SiO _2-（36-X）％CaO-4％P ₂ O ₅ -X％ZrO ₂（其中X 合成了0、5和10摩尔％的四元体系。结构和形态分析通过傅立叶变换红外光谱（FTIR），扫描电子显微镜（SEM）和X射线衍射（XRD）分析进行。然后，评估合成的BG的抗压强度。此外，通过3-（4，5二甲基噻唑-2-基）-2、5-二苯基四唑溴化物（MTT）测定，碱性磷酸酶（ALP）活性和抗菌研究来证明MC3T3的增殖和分化值如何通过添加Zr来改变E1细胞。结果显示，与其他BG相比，BG-5Zr中的抗菌百分比显着提高。通过电感耦合等离子体原子发射光谱法（ICP-AES）和pH计测量各种离子的浓度和pH值的变化。在一起