Patients who suffered from spinal cord injury (SCI) that come to healthcare professionals for diagnosis and treatment do not have electrophysiology baseline of somatosensory evoked potential (SSEP). The SSEP has always been used in research for data comparison to detect onset and severity of the SCI as well as for assessing its progress, endogenous and therapeutic recovery. This unmet need has motivated us to develop a new tool to substitute the baseline data with forelimb SSEP data of the same day. In this study, we report the development and investigation of three distinctive thoracic transections (right T10 hemi-transection (Rxl), left T8 and right T10 double hemi-transection (Dxl) and T8 complete transection (Cxl)) spinal cord injuries in an adult rat model. We used our well-established monitoring methods to obtain SSEP baselines as well as post-injury signals from days 4, 7, 14 and 21. We observed that spectral coherences obtained from non-injured spinal cord pathways are always above 0.8. The spectral coherence is dimensionless measure with values between 0 and 1 and measures the correlation between two time signals in the frequency domain. Analysis of variance (ANOVA) results also showed that there is a significant difference between the spectral coherence componanet means before and after injury with reaching p = 0.05 for Rxl, p = 0.02 for DxI, and p = 0.00 for CxI. Our signal processing enables us to replicate comparable detection of the natural history of injuries longitudinally without the implication of baseline SSEP signals, highlighting the potential of this analysis method for clinical studies.

来医护人员进行诊断和治疗的脊髓损伤（SCI）患者没有体感诱发电位（SSEP）的电生理基线。SSEP一直用于数据比较研究中，以检测SCI的发作和严重程度，以及评估其进展，内源性和治疗性恢复。这种未满足的需求促使我们开发了一种新工具，可以用当天的前肢SSEP数据替代基线数据。在这项研究中，我们报告了脊髓损伤中三种独特的胸横切（右T10半横切（Rxl），左T8和右T10双半横切（Dxl）和T8完全横切（Cxl））的发展和调查成年大鼠模型。我们使用了完善的监测方法来获得SSEP基线以及第4、7、14和21天的损伤后信号。我们观察到，从未损伤的脊髓途径获得的光谱相干性始终高于0.8。频谱相干是在0到1之间的值的无量纲测量，并且在频域中测量两个时间信号之间的相关性。方差分析（ANOVA）结果还表明，在达到损伤之前和之后，光谱相干分量均值之间存在显着差异 频谱相干是在0到1之间的值的无量纲度量，并且在频域中度量两个时间信号之间的相关性。方差分析（ANOVA）结果还表明，在达到损伤之前和之后，光谱相干分量均值之间存在显着差异 频谱相干是在0到1之间的值的无量纲测量，并且在频域中测量两个时间信号之间的相关性。方差分析（ANOVA）结果还表明，在达到损伤之前和之后，光谱相干分量均值之间存在显着差异 对于Rxl，p = 0.05，对于DxI，p  = 0.02，对于CxI，p  = 0.00。我们的信号处理使我们能够纵向复制类似的自然损伤历史检测结果，而无需使用基线SSEP信号，这突显了这种分析方法在临床研究中的潜力。