This study aimed to evaluate the effect of a lycopenesupplemented diet on a model of metabolic syndrome induced by fructose. Male Wistar rats receiving a normal diet plus tap water with 20% fructose (F) were used; half were treated simultaneously with 0.01% lycopene (FL). Rats receiving a normal diet were also divided into two groups, a control group untreated (C) and another with lycopene treatment (L). Fructose intake progressively increased the blood pressure, caused cardiac hypertrophy and endothelial dysfunction, as well as metabolic changes. Lycopene treatment significantly attenuated the development of hypertension and endothelial dysfunction and prevented cardiac hypertrophy, but had no effect in rats fed with standard diet. Others manifestations of metabolic syndrome like insulin resistance, dyslipidemia, liver enlargement, accumulation of intraperitoneal fat or oxidative stress were also improved by lycopene. In conclusion, our results suggest that lycopene significantly attenuates pathophysiological condition of metabolic syndrome caused by fructose consumption.

这项研究旨在评估补充番茄红素的饮食对果糖诱导的代谢综合征模型的影响。使用接受正常饮食加20％果糖（F）的自来水的雄性Wistar大鼠；一半患者同时接受0.01％番茄红素（FL）治疗。接受正常饮食的大鼠也分为两组，对照组未经治疗（C），另一组经番茄红素治疗（L）。果糖摄入逐渐增加血压，引起心脏肥大和内皮功能障碍，以及代谢改变。番茄红素治疗可显着减轻高血压和内皮功能障碍的发展，并预防心脏肥大，但对标准饮食喂养的大鼠没有作用。代谢综合征的其他表现，例如胰岛素抵抗，血脂异常，肝脏肿大，番茄红素还改善了腹膜内脂肪的积累或氧化应激。总之，我们的结果表明番茄红素显着减轻了果糖摄入引起的代谢综合征的病理生理状况。