Abstract By reactions of MnBr(CO)5 with 2,2′-bipyridyl-4,4′-dicarboxylic acid and 2,5-pyridinedicarboxylic acid, respectively, we obtained two new Mn-CORMs, [Mn(CO)3(H2O)(HBPDC)] (1) and [Mn(CO)3(CH3CN)(HPYDC)]·CH3CN (2). Complexes 1 and 2 are stable in the absence of light, but they exhibit good CO release ability upon exposure to UV and visible light (blue and green). The CO releasing rate depends on the wavelength of irradiation light, i.e., UV > blue > green, which may make them act as visible light regulated CORMs. It is noteworthy that complexes 1 and 2 possess high water-solubility. TD-DFT studies of complexes 1 and 2 reveal that the metal-to-ligand charge-transfer (MLCT) may be responsible for their CO releasing behaviors triggered by UV and visible light. The cellular viability and anti-inflammatory activities evaluation show that complexes 1 and 2 can inhibit the secretion of NO and TNF-α in LPS-stimulated RAW264.7 macrophages with fine biological compatibility and without apparent cytotoxicity. Furthermore, during the synthesis of complexes 1 and 2, when the pH of solution is hinger than 7, complexes {[Mn(BPDC)]}n (1A) and [Mn(H2O)2(HPYDC)2] (2A) are obtained. Complex 1A is a new 3D Mn-MOF and complex 2A is a zero-dimensional mononuclear compound, which are all without CO ligand.

中文翻译：

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水溶性紫外/可见光活化锰-CO 释放分子：合成、结构、CO 释放和生物活性评估

摘要 通过 MnBr(CO)5 分别与 2,2'-联吡啶-4,4'-二羧酸和 2,5-吡啶二羧酸反应，我们获得了两种新的 Mn-CORM，[Mn(CO)3(H2O) )(HBPDC)] (1) 和 [Mn(CO)3(CH3CN)(HPYDC)]·CH3CN (2)。配合物 1 和 2 在没有光的情况下是稳定的，但它们在暴露于紫外线和可见光（蓝色和绿色）时表现出良好的 CO 释放能力。CO 的释放速率取决于照射光的波长，即 UV > blue > green，这可能使它们充当可见光调节的 CORM。值得注意的是，配合物 1 和 2 具有高水溶性。复合物 1 和 2 的 TD-DFT 研究表明，金属到配体的电荷转移 (MLCT) 可能是其由紫外线和可见光触发的 CO 释放行为的原因。细胞活力和抗炎活性评估表明，复合物1和2可以抑制LPS刺激的RAW264.7巨噬细胞中NO和TNF-α的分泌，具有良好的生物相容性，且没有明显的细胞毒性。此外，在复合物 1 和 2 的合成过程中，当溶液的 pH 值大于 7 时，复合物 {[Mn(BPDC)]}n (1A) 和 [Mn(H2O)2(HPYDC)2] (2A) 是获得。配合物1A是新的3D Mn-MOF，配合物2A是零维单核化合物，均不含CO配体。得到复合物{[Mn(BPDC)]}n(1A)和[Mn(H2O)2(HPYDC)2](2A)。配合物1A是新的3D Mn-MOF，配合物2A是零维单核化合物，均不含CO配体。得到复合物{[Mn(BPDC)]}n(1A)和[Mn(H2O)2(HPYDC)2](2A)。配合物1A是新的3D Mn-MOF，配合物2A是零维单核化合物，均不含CO配体。