OBJECTIVE Decomposition-based quantitative electromyography (DQEMG) is one method of measuring neuromuscular physiology in human muscles. The objective of the current study is to compare the neuromuscular physiology of a typical aging population in the intrinsic hand muscles. METHODS Measurements of DQEMG were detected with a standard concentric needle and surface EMG from the intrinsic hand muscles. DQEMG was obtained from the first dorsal interosseous (FDI), the abductor digiti minimi (ADM) and fourth dorsal interosseous (4DI). Multivariate analysis of variance (MANOVA) were performed for the surface and intramuscular EMG measures to identify age differences in motor unit properties. RESULTS Large differences were observed between the age groups for the canonical intramuscular and surface EMG variables. Older adults demonstrated a large decrease in motor unit number estimation in the ADM and FDI. Likewise, medium to large decreases in motor unit stability were observed in the FDI, ADM and 4DI. CONCLUSIONS With aging, there are decreases in motor unit number estimation and stability in the intrinsic hand muscles. Using a multivariate approach allows for age-related differences and the relationship between the variables to be further elucidated. SIGNIFICANCE Multivariate analysis of DQEMG may be useful for identifying patterns of change in neuromuscular physiology with age-related changes to hand musculature. This may potentially lead to future prognostic biomarkers of age-related changes to hand muscles.

中文翻译：

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评估手部内在肌肉中基于分解的定量 EMG 的年龄相关差异：一种多元方法

目标基于分解的定量肌电图 (DQEMG) 是一种测量人体肌肉神经肌肉生理学的方法。当前研究的目的是比较典型老龄化人群的内在手部肌肉的神经肌肉生理学。方法 DQEMG 的测量是用标准的同心针和来自手部内在肌肉的表面肌电图检测到的。DQEMG 来自第一背侧骨间 (FDI)、小指外展肌 (ADM) 和第四背侧骨间 (4DI)。对表面和肌内 EMG 测量进行多变量方差分析 (MANOVA)，以识别运动单位特性的年龄差异。结果 在典型的肌内和表面肌电图变量的年龄组之间观察到很大差异。在 ADM 和 FDI 中，老年人的运动单位数量估计值大幅下降。同样，在 FDI、ADM 和 4DI 中观察到运动单元稳定性中到大的下降。结论随着年龄的增长，手部内在肌肉的运动单位数量估计和稳定性下降。使用多变量方法可以进一步阐明与年龄相关的差异和变量之间的关系。意义 DQEMG 的多变量分析可能有助于识别与年龄相关的手部肌肉组织变化的神经肌肉生理学变化模式。这可能会导致未来手部肌肉年龄相关变化的预后生物标志物。ADM 和 4DI。结论随着年龄的增长，手部内在肌肉的运动单位数量估计和稳定性下降。使用多变量方法可以进一步阐明与年龄相关的差异和变量之间的关系。意义 DQEMG 的多变量分析可能有助于识别与年龄相关的手部肌肉组织变化的神经肌肉生理学变化模式。这可能会导致未来手部肌肉年龄相关变化的预后生物标志物。ADM 和 4DI。结论随着年龄的增长，手部内在肌肉的运动单位数量估计和稳定性下降。使用多变量方法可以进一步阐明与年龄相关的差异和变量之间的关系。意义 DQEMG 的多变量分析可能有助于识别与年龄相关的手部肌肉组织变化的神经肌肉生理学变化模式。这可能会导致未来手部肌肉年龄相关变化的预后生物标志物。意义 DQEMG 的多变量分析可能有助于识别与年龄相关的手部肌肉组织变化的神经肌肉生理学变化模式。这可能会导致未来手部肌肉年龄相关变化的预后生物标志物。意义 DQEMG 的多变量分析可能有助于识别与年龄相关的手部肌肉组织变化的神经肌肉生理学变化模式。这可能会导致未来手部肌肉年龄相关变化的预后生物标志物。