A recent work published in Science by Cramer and co-workers demonstrates chiral cyclometalated Ir(III) complexes can selectively catalyze the hydrogenation of carbon-nitrogen double bond of oximes with the aid of acid. Various oximes can be hydrogenated to the corresponding N-alkoxy amines in good to excellent yields with good enantioselectivity.

中文翻译：

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肟的高度选择性不对称氢化为羟胺衍生物

Cramer及其同事在Science上发表的最新研究表明，手性环金属化的Ir（III）配合物可以借助酸选择性催化肟的碳-氮双键加氢。可以将各种肟以良好的对映选择性，以良好或优异的产率氢化成相应的N-烷氧基胺。