Background

Deep-brain stimulation is a well-established, effective treatment for patients with advanced Parkinson’s disease. Recent studies examining rates of suicide attempts and suicides after deep-brain stimulation in the bilateral subthalamic nucleus have reported varying results. Using this systematic review and meta-analysis, we aim to obtain a comprehensive understanding of suicidality in Parkinson’s patients after subthalamic nucleus deep brain stimulation.

Methods

We systematically examined Medline, PubMed, Web of Science, and Embase databases to identify studies published before November 2019 that measured rates of suicidality in Parkinson’s patients who underwent subthalamic nucleus stimulation. A meta-analysis of the data from the included studies was conducted using Stata 12.0.

Results

A total of 18 studies met the eligibility criteria of this study. We found that the pooled rate of suicidal ideation was 4% (95% CI 0.00–7.2%, range 2–17%). The pooled rate of suicide attempts was 1% (95% CI 1.0–2.0%), while the pooled rate of suicide was 1% (95% CI 0.0–1.0%).

Conclusions

Our findings indicate a relatively high rate of suicidality among Parkinson’s patients after subthalamic nucleus deep-brain stimulation. It is important for clinicians to carefully monitor psychiatric disorders, especially suicidal ideation and suicide attempts, in Parkinson’s patients before and after subthalamic nucleus deep-brain stimulation.

中文翻译：

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丘脑底核刺激后帕金森氏病的自杀和自杀尝试：系统评价和荟萃分析。

背景

深脑刺激是针对晚期帕金森氏病患者的行之有效的有效治疗方法。最近的研究检查了双侧丘脑底核深层刺激后自杀未遂率和自杀率的研究报告了不同的结果。使用这项系统的综述和荟萃分析，我们旨在全面了解丘脑下丘脑深部脑刺激后帕金森氏病患者的自杀倾向。

方法

我们系统地检查了Medline，PubMed，Web of Science和Embase数据库，以识别2019年11月之前发表的研究，该研究测量了受到丘脑底核刺激的帕金森氏病患者的自杀率。使用Stata 12.0对纳入研究的数据进行荟萃分析。

结果

共有18项研究符合该研究的入选标准。我们发现自杀意念的合并率为4％（95％CI为0.00–7.2％，范围为2–17％）。自杀未遂合并率为1％（95％CI为1.0–2.0％），自杀未遂合并率为1％（95％CI为0.0–1.0％）。

结论

我们的发现表明，丘脑底核深脑刺激后帕金森氏病患者的自杀率相对较高。对于临床医生而言，在丘脑底核深脑刺激之前和之后，仔细监测帕金森氏病患者的精神疾病，尤其是自杀意念和自杀企图非常重要。