Abstract Idiopathic intracranial hypertension (IIH) is one of the chronic causes of elevated intracranial pressure with no evident cause in neuroimaging and normal CSF analysis. It primarily affects overweight women of childbearing age. Aim of work To describe the clinical picture of IIH, neuroimaging and response to treatment after 3 months follow up in a sample of Egyptian patients. Patients and methods This was a prospective study carried out on 25 patients presented at Alexandria University Hospital with symptomatology of IIH. All the patients were subjected to complete history taking, neurological examination, fundus examination, lumbar puncture, and MRI brain and MR cerebral venography. The patients were followed-up for 3 months for assessment of treatment response. Results Patients’ ages ranged from 1 0to 50 years, with a mean BMI 32.32 ± 5.28 kg m 2 . Headache was the presenting manifestation in 100% of the patients. About 60% of the sample were either misdiagnosed or had a delayed diagnosis. There was a significant positive correlation between CSF opening pressure ( r = 0.504, p = 0.010), severity of headache ( r = 0.472, p = 0.017) and grade of papilledema. Optic hydropes and empty sellaturcica were the most common MRI abnormalities occurring in 95.8% and 70.8%, respectively. Only 30% of the cases had normal MRV. Stenosis at genu junction and focal stenosis at transverse sinus occurred in 24% and 20% of the cases, respectively. Combined medical and serial lumbar puncture were the most effective line of therapy in the recruited patients. Conclusion Headache is the most common presentation of IIH, and its severity is positively correlated with papilledema grade. CSF pressure is also positively correlated with papilledema grade.

中文翻译：

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特发性颅内高压患者的临床和放射学研究

摘要 特发性颅内高压（IIH）是导致颅内压升高的慢性原因之一，神经影像学和脑脊液分析正常均无明显原因。它主要影响超重的育龄妇女。工作目的 在埃及患者样本中描述 3 个月随访后 IIH 的临床表现、神经影像学和对治疗的反应。患者和方法 这是一项前瞻性研究，对在亚历山大大学医院就诊的 25 名有 IIH 症状的患者进行。所有患者均进行了完整的病史采集、神经系统检查、眼底检查、腰椎穿刺、MRI脑和MR脑静脉造影。对患者进行 3 个月的随访以评估治疗反应。结果患者年龄1 0～50岁，平均BMI 32.32±5。28 公斤米 2 。头痛是 100% 患者的主要表现。大约 60% 的样本被误诊或延误诊断。脑脊液开放压力 (r = 0.504, p = 0.010)、头痛严重程度 (r = 0.472, p = 0.017) 和视乳头水肿等级呈显着正相关。视神经水肿和空蝶鞍是最常见的 MRI 异常，分别发生在 95.8% 和 70.8%。只有 30% 的病例具有正常的 MRV。膝关节处狭窄和横窦局灶性狭窄分别发生在 24% 和 20% 的病例中。联合医学和连续腰椎穿刺是招募患者中最有效的治疗方法。结论头痛是IIH最常见的表现，其严重程度与视乳头水肿分级呈正相关。